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Slc47a1 Gene Detail
Summary
  • Symbol
    Slc47a1
  • Name
    solute carrier family 47, member 1
  • Synonyms
    1300013J15Rik, MATE1, mMATE1, mMATE1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914723
    NCBI Gene: 67473
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:61234227-61269171 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 37.96 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    912 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914723
 protein coding gene Chr11:61234226-61269668 (-)
129S1/SvImJ ENSMUSG00200034213
 protein coding gene Chr11:58159064-58194033 (-)
A/J ENSMUSG00195038095
 protein coding gene Chr11:58193523-58228491 (-)
AKR/J ENSMUSG00220037315
 protein coding gene Chr11:58301201-58336159 (-)
BALB/cJ ENSMUSG00180046964
 protein coding gene Chr11:58246632-58281592 (-)
C3H/HeJ ENSMUSG00175040087
 protein coding gene Chr11:58210769-58245710 (-)
C57BL/6NJ ENSMUSG00215020407
 protein coding gene Chr11:57953693-57988649 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016475
 protein coding gene Chr11:56168649-56203422 (-)
CAST/EiJ ENSTCUG00005038503
 protein coding gene Chr11:57746483-57781560 (-)
CBA/J ENSMUSG00210029598
 protein coding gene Chr11:58043803-58078746 (-)
DBA/2J ENSMUSG00185042962
 protein coding gene Chr11:58233251-58268216 (-)
FVB/NJ ENSMUSG00205026894
 protein coding gene Chr11:58118470-58153413 (-)
JF1/MsJ ENSUMUG00000039802
 protein coding gene Chr11:58641540-58676495 (-)
LP/J ENSMUSG00230048563
 protein coding gene Chr11:59380363-59415327 (-)
NOD/ShiLtJ ENSMUSG00190035408
 protein coding gene Chr11:58227463-58262403 (-)
NZO/HlLtJ ENSMUSG00225042636
 protein coding gene Chr11:61523693-61558684 (-)
PWK/PhJ ENSLUMG00010034733
 protein coding gene Chr11:58164268-58199211 (-)
SPRET/EiJ ENSMSPG00010031780
 protein coding gene Chr11:58834934-58870634 (-)
WSB/EiJ ENSIUOG00005032702
 protein coding gene Chr11:58151059-58186034 (-)



Homology
more
  • Human Ortholog
    SLC47A1, solute carrier family 47 member 1
  • Vertebrate Orthologs
    8
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC47A1, solute carrier family 47 member 1
  • Synonyms
    MATE1
  • Links
    NCBI Gene ID: 55244
    UniProt: Q96FL8

  • Chr Location
    17p11.2; chr17:19495385-19579034 (+)  GRCh38
  • Human Ortholog
    SLC47A2, solute carrier family 47 member 2
  • Synonyms
    MATE2, MATE2-B, MATE2-K, MATE2K
  • Links
    NCBI Gene ID: 146802
    UniProt: Q86VL8

  • Chr Location
    17p11.2; chr17:19678288-19718979 (-)  GRCh38
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 3 genetic backgrounds
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased blood urea nitrogen, increased circulating creatinine, and abnormal metformin pahrmacokinetics including increased plasma and tissue concentration with decreased kidney and liver clearance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    66
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    821
  • Tissues
    187
  • cDNA Data
    52
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000010122 Ensembl Gene Model | MGI Sequence Detail 34945 C57BL/6J ±  kb
    transcript ENSMUST00000010267 Ensembl | MGI Sequence Detail 2639 Not Applicable  
    polypeptide ENSMUSP00000010267 Ensembl | MGI Sequence Detail 567 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000015152 multidrug and toxin extrusion protein 1
      (term hierarchy)
    • InterPro Domains
      IPR002528 Multi antimicrobial extrusion protein
      IPR045069 Multidrug and toxic compound extrusion family, eukaryotic
    Molecular
    Reagents
    less
    • All nucleic 56
      cDNA 52
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2144064
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 8
      Diseases 2
      Gene Ontology 12
      Phenotypes 35
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:366215 Rudat C, et al., PPARG contributes to urothelial integrity in the murine ureter by activating the expression of Shh and superficial cell-specific genes. Development. 2025 Apr 15;152(8)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory