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Foxo3 Gene Detail
Summary
  • Symbol
    Foxo3
  • Name
    forkhead box O3
  • Synonyms
    1110048B16Rik, 2010203A17Rik, Fkhr2, FKHRL1, Foxo3a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890081
    NCBI Gene: 56484
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:42057841-42152691 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 22.79 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    728 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890081
 protein coding gene Chr10:42057837-42152751 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017183
 protein coding gene Chr10:40873152-40970975 (-)
A/J MGP_AJ_G0017160
 protein coding gene Chr10:39724258-39819536 (-)
AKR/J MGP_AKRJ_G0017120
 protein coding gene Chr10:40335620-40430558 (-)
BALB/cJ MGP_BALBcJ_G0017122
 protein coding gene Chr10:39789207-39883223 (-)
C3H/HeJ MGP_C3HHeJ_G0016943
 protein coding gene Chr10:40668965-40764418 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017581
 protein coding gene Chr10:42119869-42215431 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015277
 protein coding gene Chr10:37600701-37697166 (-)
CAST/EiJ MGP_CASTEiJ_G0016522
 protein coding gene Chr10:40857312-40954976 (-)
CBA/J MGP_CBAJ_G0016917
 protein coding gene Chr10:44039159-44138745 (-)
DBA/2J MGP_DBA2J_G0017022
 protein coding gene Chr10:39217162-39313361 (-)
FVB/NJ MGP_FVBNJ_G0017017
 protein coding gene Chr10:38711954-38812883 (-)
LP/J MGP_LPJ_G0017099
 protein coding gene Chr10:40875610-40975629 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017047
 protein coding gene Chr10:44807353-44908325 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017618
 protein coding gene Chr10:40299763-40396681 (-)
PWK/PhJ MGP_PWKPhJ_G0016302
 protein coding gene Chr10:39102237-39190669 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016086
 protein coding gene Chr10:40114830-40213311 (-)
WSB/EiJ MGP_WSBEiJ_G0016585
 protein coding gene Chr10:40610708-40706675 (-)



Homology
more
  • Human Ortholog
    FOXO3, forkhead box O3
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FOXO3, forkhead box O3
  • Synonyms
    AF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A
  • Links
    NCBI Gene ID: 2309
    neXtProt AC: NX_O43524
    UniProt: O43524

  • Chr Location
    6q21; chr6:108559825-108684774 (+)  GRCh38
  • Human Ortholog
    FOXO3B, forkhead box O3B
  • Synonyms
    FKHRL1P1, ZNF286C
  • Links
    NCBI Gene ID: 2310
    UniProt: A0A2Z4LIS9

  • Chr Location
    17p11.2; chr17:18667629-18682314 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Foxo3 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    73 phenotypes from 7 alleles in 9 genetic backgrounds
    29 phenotypes from multigenic genotypes
    189 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Inactivation of the locus results in an ovarian defect involving follicular growth activation and leads progressively to female sterility. For some alleles defects in immune system function and hematopoiesis have also been reported.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    100
  • GO References
    30
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1066
  • Tissues
    235
  • cDNA Data
    21
  • Literature Summary
    63
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56484 NCBI Gene Model | MGI Sequence Detail 94851 C57BL/6J ±  kb
    transcript NM_001376967 RefSeq | MGI Sequence Detail 6787 ZRU/MplStud  
    polypeptide Q9WVH4 UniProt | EBI | MGI Sequence Detail 672 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 21
      Primer pair 5
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1916006, MGI:1917519, MGI:2143914
    References
    more
    • Summaries
      All 403
      Developmental Gene Expression 63
      Diseases 3
      Gene Ontology 30
      Phenotypes 189
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345016 Penniman CM, et al., Loss of FoxOs in muscle increases strength and mitochondrial function during aging. J Cachexia Sarcopenia Muscle. 2023 Feb;14(1):243-259
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory