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Esrra Gene Detail
Summary
  • Symbol
    Esrra
  • Name
    estrogen related receptor, alpha
  • Synonyms
    Err1, ERRalpha, Estrra, Nr3b1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346831
    NCBI Gene: 26379
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:6888345-6899182 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 19, 5.08 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    97 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346831
protein coding gene Chr19:6888345-6899208 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024770
protein coding gene Chr19:4000723-4011338 (-)
A/J MGP_AJ_G0024736
protein coding gene Chr19:3671552-3683092 (-)
AKR/J MGP_AKRJ_G0024709
protein coding gene Chr19:3787916-3798576 (-)
BALB/cJ MGP_BALBcJ_G0024736
protein coding gene Chr19:3781778-3792375 (-)
C3H/HeJ MGP_C3HHeJ_G0024504
protein coding gene Chr19:3914788-3925428 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025182
protein coding gene Chr19:4088753-4102965 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022616
protein coding gene Chr19:3581246-3592230 (-)
CAST/EiJ MGP_CASTEiJ_G0023976
protein coding gene Chr19:3823211-3835253 (-)
CBA/J MGP_CBAJ_G0024476
protein coding gene Chr19:4137717-4152539 (-)
DBA/2J MGP_DBA2J_G0024603
protein coding gene Chr19:3645858-3656673 (-)
FVB/NJ MGP_FVBNJ_G0024569
protein coding gene Chr19:3674370-3685206 (-)
LP/J MGP_LPJ_G0024689
protein coding gene Chr19:3863466-3874101 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024598
protein coding gene Chr19:4045495-4057327 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025230
protein coding gene Chr19:3922361-3933326 (-)
PWK/PhJ MGP_PWKPhJ_G0023722
protein coding gene Chr19:3687864-3699945 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023527
protein coding gene Chr19:3741468-3755791 (-)
WSB/EiJ MGP_WSBEiJ_G0024038
protein coding gene Chr19:3823023-3835437 (-)



Homology
more
  • Human Ortholog
    ESRRA, estrogen related receptor alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ESRRA, estrogen related receptor alpha
  • Synonyms
    ERR1, ERRa, ERRalpha, ESRL1, NR3B1
  • Links
    NCBI Gene ID: 2101
    neXtProt AC: NX_P11474
    UniProt: P11474

  • Chr Location
    11q13.1; chr11:64305497-64316743 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 4 alleles in 6 genetic backgrounds
    56 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice for one mutation were viable but showed reduced weight gain associated with decreased peripheral fat deposition. Mutant mice were resistant to high-fat diet induced obesity. Another targeted mutation resulted in no significant abnormalities in homozygotes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26379 NCBI Gene Model | MGI Sequence Detail 10838 C57BL/6J ±  kb
    transcript NM_001413228 RefSeq | MGI Sequence Detail 2345 ZRU/MplStud  
    polypeptide O08580 UniProt | EBI | MGI Sequence Detail 422 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 63
      cDNA 58
      Primer pair 4
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-35850, MGI:107383
    References
    more
    • Summaries
      All 135
      Developmental Gene Expression 27
      Gene Ontology 8
      Phenotypes 56
    • Earliest
      J:31609 Pettersson K, et al., Expression of a novel member of estrogen response element-binding nuclear receptors is restricted to the early stages of chorion formation during mouse embryogenesis. Mech Dev. 1996 Feb;54(2):211-23
    • Latest
      J:342224 Xia H, et al., Hepatocyte FBXW7-dependent activity of nutrient-sensing nuclear receptors controls systemic energy homeostasis and NASH progression in male mice. Nat Commun. 2023 Nov 1;14(1):6982

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory