Phf11d MGI Mouse Gene Detail - MGI:1277133

Symbol

Phf11d
Name

PHD finger protein 11D
Synonyms

D14Ertd668e

Feature Type

protein coding gene
IDs

MGI:1277133
NCBI Gene: 219132
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr14:59584856-59602919 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 31.48 cM
Mapping Data

2 experiments

SNPs within 2kb

599 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1277133	protein coding gene	Chr14:59584646-59608004 (-)
129S1/SvImJ	ENSMUSG00200040678	protein coding gene	Chr14:48170747-48188810 (-)
A/J	ENSMUSG00195032548	protein coding gene	Chr14:48388158-48406218 (-)
AKR/J	ENSMUSG00220024762	protein coding gene	Chr14:47726142-47744209 (-)
BALB/cJ	ENSMUSG00180049301	protein coding gene	Chr14:48010148-48028212 (-)
C3H/HeJ	ENSMUSG00175045754	protein coding gene	Chr14:49728883-49746955 (-)
C57BL/6NJ	ENSMUSG00215048107	protein coding gene	Chr14:47908796-47926861 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019362	protein coding gene	Chr14:50586160-50630478 (-)
CAST/EiJ	ENSTCUG00005046258	protein coding gene	Chr14:49682371-49700459 (-)
CBA/J	ENSMUSG00210044956	protein coding gene	Chr14:48378381-48396446 (-)
DBA/2J	ENSMUSG00185030070	protein coding gene	Chr14:53527096-53545166 (-)
FVB/NJ	ENSMUSG00205020010	protein coding gene	Chr14:47812438-47830504 (-)
JF1/MsJ	ENSUMUG00000045626	protein coding gene	Chr14:64752826-64770886 (-)
LP/J	ENSMUSG00230032424	protein coding gene	Chr14:65539715-65557778 (-)
NOD/ShiLtJ	ENSMUSG00190027149	protein coding gene	Chr14:48142679-48160742 (-)
NZO/HlLtJ	ENSMUSG00225044591	protein coding gene	Chr14:55884264-55902327 (-)
PWK/PhJ	ENSLUMG00010042011	protein coding gene	Chr14:47595442-47613508 (-)
SPRET/EiJ	ENSMSPG00010031714	protein coding gene	Chr14:51047923-51067320 (-)
WSB/EiJ	ENSIUOG00005036693	protein coding gene	Chr14:47574646-47592725 (-)

Human Ortholog

PHF11, PHD finger protein 11

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PHF11, PHD finger protein 11
Synonyms

APY, BCAP, IGEL, IGER, IGHER, NY-REN-34, NYREN34
Links

HGNC:17024

NCBI Gene ID: 51131

UniProt: Q9UIL8
Chr Location

13q14.2; chr13:49495095-49528981 (+) GRCh38

MGI Vertebrate Homology

Phf11d stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PHF11
Gene Tree

Phf11d

Diseases

4 with human PHF11 associations

				Human Disease	Mouse Models
				allergic disease IDs allergic disease DOID:1205 ICD10CM:T78.40 MESH:D006967 NCI:C3114 UMLS_CUI:C0020517
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096
				atopic dermatitis IDs atopic dermatitis DOID:3310 EFO:0000274 ICD10CM:L20 MESH:D003876 NCI:C211594 OMIM:603165 OMIM:PS603165 UMLS_CUI:C0011615
				childhood-onset asthma IDs childhood-onset asthma DOID:0080815

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

40
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

33
Targeted

2
Genomic Mutations

1 involving Phf11d
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

28 strains or lines available

Mice homozygous for an ENU mutated allele exhibit a change in the expression levels of immune response gene after LPS exposure.

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All GO Annotations

4
GO References

3

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

649
Tissues

12
cDNA Data

19
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

61
RefSeq

22
UniProt

2
CCDS

CCDS27170.3

Ensembl

ENSMUSG00000068245 (Evidence)
NCBI Gene

219132

			Length	Strain/Species	Flank
genomic	ENSMUSG00000068245	Ensembl Gene Model \| MGI Sequence Detail	18064	C57BL/6J	± kb
transcript	ENSMUST00000161031	Ensembl \| MGI Sequence Detail	1130	Not Applicable
polypeptide	ENSMUSP00000125181	Ensembl \| MGI Sequence Detail	337	Not Applicable

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UniProt

2 Sequences
InterPro Domains

IPR034732 Extended PHD (ePHD) domain

IPR051188 PHD-type Zinc Finger Domain-Containing Protein

IPR011011 Zinc finger, FYVE/PHD-type

IPR001965 Zinc finger, PHD-type

IPR013083 Zinc finger, RING/FYVE/PHD-type

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All nucleic 21

cDNA 19

Primer pair 2

Microarray probesets 2

Summaries

All 37

Developmental Gene Expression 4

Gene Ontology 3

Phenotypes 11
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:388027 Wang W, et al., CCDC174 deficiency impaired human fertility by affecting the alternative splicing of maternal mRNAs. EMBO Mol Med. 2026 Jun;18(6):2436-2454

TSS for Phf11d:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr129001	Chr14:59602914-59602936 (-)	-6 bp
Tssr129000	Chr14:59602883-59602910 (-)	22 bp
Tssr128999	Chr14:59602869-59602880 (-)	44 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24