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Birc5 Gene Detail
Summary
  • Symbol
    Birc5
  • Name
    baculoviral IAP repeat-containing 5
  • Synonyms
    Api4, survivin, TIAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1203517
    NCBI Gene: 11799
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:117740077-117746569 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 82.96 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    275 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1203517
 protein coding gene Chr11:117740063-117746569 (+)
129S1/SvImJ ENSMUSG00200049543
 protein coding gene Chr11:115107910-115114402 (+)
A/J ENSMUSG00195028449
 protein coding gene Chr11:114782488-114788977 (+)
AKR/J ENSMUSG00220030291
 protein coding gene Chr11:114933013-114939506 (+)
BALB/cJ ENSMUSG00180047004
 protein coding gene Chr11:115067544-115074038 (+)
C3H/HeJ ENSMUSG00175035616
 protein coding gene Chr11:115034124-115040616 (+)
C57BL/6NJ ENSMUSG00215042984
 protein coding gene Chr11:114601439-114607931 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017473
 protein coding gene Chr11:113729491-113734791 (+)
CAST/EiJ ENSTCUG00005031208
 protein coding gene Chr11:114458479-114465020 (+)
CBA/J ENSMUSG00210048567
 protein coding gene Chr11:114748200-114754692 (+)
DBA/2J ENSMUSG00185023285
 protein coding gene Chr11:115061246-115067738 (+)
FVB/NJ ENSMUSG00205041704
 protein coding gene Chr11:114906316-114912809 (+)
JF1/MsJ ENSUMUG00000041297
 protein coding gene Chr11:115344408-115350917 (+)
LP/J ENSMUSG00230049969
 protein coding gene Chr11:116127205-116133697 (+)
NOD/ShiLtJ ENSMUSG00190046724
 protein coding gene Chr11:115128264-115134757 (+)
NZO/HlLtJ ENSMUSG00225050837
 protein coding gene Chr11:118275373-118281866 (+)
PWK/PhJ ENSLUMG00010023693
 protein coding gene Chr11:114862298-114868708 (+)
SPRET/EiJ ENSMSPG00010031326
 protein coding gene Chr11:115428632-115434964 (+)
WSB/EiJ ENSIUOG00005046265
 protein coding gene Chr11:114867054-114873549 (+)



Homology
more
  • Human Ortholog
    BIRC5, baculoviral IAP repeat containing 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BIRC5, baculoviral IAP repeat containing 5
  • Synonyms
    API4, EPR-1
  • Links
    NCBI Gene ID: 332
    UniProt: O15392

  • Chr Location
    17q25.3; chr17:78214186-78225636 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human BIRC5 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 6 alleles in 6 genetic backgrounds
    10 phenotypes from multigenic genotypes
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants die during early embryonic development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    106
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    873
  • Tissues
    204
  • cDNA Data
    95
  • Literature Summary
    70
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000017716 Ensembl Gene Model | MGI Sequence Detail 6493 C57BL/6J ±  kb
    transcript ENSMUST00000081387 Ensembl | MGI Sequence Detail 947 Not Applicable  
    polypeptide ENSMUSP00000079124 Ensembl | MGI Sequence Detail 140 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 104
      Genomic 1
      cDNA 98
      Primer pair 5
      Antibodies 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1196343
    References
    more
    • Summaries
      All 240
      Developmental Gene Expression 70
      Gene Ontology 16
      Phenotypes 50
    • Earliest
      J:42738 Tewari M, et al., AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal. Cancer Res. 1997 Sep 15;57(18):4063-9
    • Latest
      J:390780 Qasrawi F, et al., DeltaNP63 regulates epithelial stratification and differentiation in the murine ureter. Am J Physiol Renal Physiol. 2026 Aug 1;331(2):F286-F303
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory