Ctnnd2 MGI Mouse Gene Detail - MGI:1195966 - catenin delta 2

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Ctnnd2 Gene Detail

Symbol

Ctnnd2
Name

catenin delta 2
Synonyms

catenin (cadherin associated protein), delta 2, Catnd2, neurojugin, Nprap

Feature Type

protein coding gene
IDs

MGI:1195966
NCBI Gene: 18163
Alliance

genome feature page
Transcription Start Sites

29 TSS

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Sequence Map

Chr15:30172739-31029487 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 12.02 cM
Mapping Data

1 experiment

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SNPs within 2kb

27098 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_1195966	protein coding gene	Chr15:30172680-31029490 (+)
129S1/SvImJ	ENSMUSG00200027365	protein coding gene	Chr15:27239823-28078789 (+)
A/J	ENSMUSG00195013573	protein coding gene	Chr15:27106822-27964368 (+)
AKR/J	ENSMUSG00220024098	protein coding gene	Chr15:26989051-27847070 (+)
BALB/cJ	ENSMUSG00180005332	protein coding gene	Chr15:27066470-27918411 (+)
C3H/HeJ	ENSMUSG00175004631	protein coding gene	Chr15:27224101-28081790 (+)
C57BL/6NJ	ENSMUSG00215004914	protein coding gene	Chr15:27083185-27940836 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019706	protein coding gene	Chr15:25405836-26198775 (+)
CAST/EiJ	ENSTCUG00005014627	protein coding gene	Chr15:27205881-28016338 (+)
CBA/J	ENSMUSG00210024073	protein coding gene	Chr15:27178130-28035786 (+)
DBA/2J	ENSMUSG00185022980	protein coding gene	Chr15:27163576-28021194 (+)
FVB/NJ	ENSMUSG00205012704	protein coding gene	Chr15:27061439-27912434 (+)
JF1/MsJ	ENSUMUG00000009793	protein coding gene	Chr15:27160526-27999865 (+)
LP/J	ENSMUSG00230015002	protein coding gene	Chr15:30639182-31478742 (+)
NOD/ShiLtJ	ENSMUSG00190011633	protein coding gene	Chr15:27145836-28016907 (+)
NZO/HlLtJ	ENSMUSG00225030466	protein coding gene	Chr15:30875082-31723434 (+)
PWK/PhJ	ENSLUMG00010020907	protein coding gene	Chr15:27294182-28146044 (+)
SPRET/EiJ	ENSMSPG00010022509	protein coding gene	Chr15:27834444-28695020 (+)
WSB/EiJ	ENSIUOG00005019997	protein coding gene	Chr15:27170022-28018265 (+)

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Human Ortholog

CTNND2, catenin delta 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CTNND2, catenin delta 2
Synonyms

GT24, NPRAP
Links

HGNC:2516

NCBI Gene ID: 1501

UniProt: Q9UQB3
Chr Location

5p15.2; chr5:10971836-11904446 (-) GRCh38

MGI Vertebrate Homology

Ctnnd2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CTNND2
Gene Tree

Ctnnd2

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Diseases

3 with human CTNND2 associations

				Human Disease	Mouse Models
				anxiety disorder IDs anxiety disorder DOID:2030 DOID:12884 ICD10CM:F41.9 ICD9CM:300.09 MESH:D001008 NCI:C2878 OMIM:607834 UMLS_CUI:C0003469
				major depressive disorder IDs major depressive disorder DOID:1470 DOID:10614 DOID:2240 DOID:2241 DOID:7580 ICD10CM:F32 ICD10CM:F33.9 ICD9CM:296.2 ICD9CM:296.20 ICD9CM:296.3 ICD9CM:296.30 NCI:C195908 NCI:C34796 OMIM:608516 OMIM:608520 OMIM:608691 UMLS_CUI:C0024517 UMLS_CUI:C0154409
				schizophrenia IDs schizophrenia DOID:5419 DOID:14734 ICD10CM:F20 ICD9CM:295 ICD9CM:295.8 ICD9CM:295.80 ICD9CM:295.9 ICD9CM:295.90 MESH:D012559 NCI:C3362 OMIM:181500 UMLS_CUI:C0036341

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
22 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

2
Endonuclease-mediated

9
Targeted

1
Genomic Mutations

2 involving Ctnnd2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

66 strains or lines available

Mice homozygous for a reporter allele exhibit abnormal conditioning, spatial learning and coordination behaviors and abnormal long term potentiation.

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All GO Annotations

35
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

790
Tissues

106
cDNA Data

79
Literature Summary

12

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ctnnd2

ZFIN ctnnd2a, ctnnd2b

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All Sequences

77
RefSeq

12
UniProt

11
CCDS

CCDS27405.1, CCDS88745.1

Ensembl

ENSMUSG00000022240 (Evidence)
NCBI Gene

18163

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000022240	Ensembl Gene Model \| MGI Sequence Detail	856749	C57BL/6J	± kb
	transcript	ENSMUST00000081728	Ensembl \| MGI Sequence Detail	5944	Not Applicable
	polypeptide	ENSMUSP00000080427	Ensembl \| MGI Sequence Detail	1246	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000006013 catenin delta-2

(term hierarchy)
InterPro Domains

IPR000225 Armadillo

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR028435 Plakophilin/Delta catenin
GlyGen

O35927 36 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (34 sites)

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All nucleic 82

cDNA 80

Primer pair 2

Antibodies 5

Microarray probesets 4

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Summaries

All 70

Developmental Gene Expression 12

Gene Ontology 12

Phenotypes 22
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:392232 Hinchliffe ES, et al., delta-catenin haploinsufficiency is sufficient to alter behaviors and glutamatergic synapses in mice. Neuroscience. 2026 Feb 4;598:63-71

TSS for Ctnnd2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr130913	Chr15:30172665-30172713 (+)	-50 bp
Tssr130914	Chr15:30172716-30172746 (+)	-8 bp
Tssr130915	Chr15:30172800-30172811 (+)	67 bp
Tssr130916	Chr15:30172824-30172877 (+)	112 bp
Tssr130917	Chr15:30172887-30172914 (+)	162 bp
Tssr130924	Chr15:30303597-30303600 (+)	130,860 bp
Tssr130925	Chr15:30333353-30333360 (+)	160,618 bp
Tssr130926	Chr15:30333977-30333994 (+)	161,247 bp
Tssr130927	Chr15:30338601-30338604 (+)	165,864 bp
Tssr130928	Chr15:30457737-30457745 (+)	285,002 bp
Tssr130929	Chr15:30457773-30457856 (+)	285,076 bp
Tssr130930	Chr15:30457997-30458014 (+)	285,267 bp
Tssr130931	Chr15:30486009-30486026 (+)	313,279 bp
Tssr130935	Chr15:30539729-30539742 (+)	366,997 bp
Tssr130936	Chr15:30633128-30633131 (+)	460,391 bp
Tssr130937	Chr15:30634839-30634855 (+)	462,108 bp
Tssr130938	Chr15:30634889-30634902 (+)	462,157 bp
Tssr130939	Chr15:30646381-30646383 (+)	473,643 bp
Tssr130940	Chr15:30646660-30646718 (+)	473,950 bp
Tssr130941	Chr15:30646728-30646745 (+)	473,998 bp
Tssr130942	Chr15:30646813-30646832 (+)	474,084 bp
Tssr130943	Chr15:30646849-30646862 (+)	474,117 bp
Tssr130944	Chr15:30646879-30646921 (+)	474,161 bp
Tssr130945	Chr15:30646993-30647057 (+)	474,286 bp
Tssr130946	Chr15:30647082-30647102 (+)	474,353 bp
Tssr130947	Chr15:30647154-30647230 (+)	474,453 bp
Tssr130948	Chr15:30730351-30730357 (+)	557,615 bp
Tssr130949	Chr15:31004918-31004944 (+)	832,192 bp
Tssr130950	Chr15:31027920-31027926 (+)	855,184 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29