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H3f3b Gene Detail
Summary
  • Symbol
    H3f3b
  • Name
    H3.3 histone B
  • Synonyms
    9430068D06Rik, H3-3b, H3.3B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1101768
    NCBI Gene: 15081
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:115912738-115918788 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 80.91 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    26 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1101768
 protein coding gene Chr11:115912738-115921313 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019410
 protein coding gene Chr11:120102778-120111377 (-)
A/J MGP_AJ_G0019379
 protein coding gene Chr11:114856180-114857332 (-)
AKR/J MGP_AKRJ_G0019349
 protein coding gene Chr11:118283444-118290130 (-)
BALB/cJ MGP_BALBcJ_G0019353
 protein coding gene Chr11:115266897-115275497 (-)
C3H/HeJ MGP_C3HHeJ_G0019159
 protein coding gene Chr11:118632161-118638078 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019803
 protein coding gene Chr11:123768233-123787480 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017426
 protein coding gene Chr11:111874008-111879695 (-)
CAST/EiJ MGP_CASTEiJ_G0018714
 protein coding gene Chr11:119979379-119986416 (-)
CBA/J MGP_CBAJ_G0019131
 protein coding gene Chr11:128669384-128676862 (-)
DBA/2J MGP_DBA2J_G0019242
 protein coding gene Chr11:114273348-114279615 (-)
FVB/NJ MGP_FVBNJ_G0019234
 protein coding gene Chr11:113784420-113785384 (-)
LP/J MGP_LPJ_G0019312
 protein coding gene Chr11:120484573-120491098 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019267
 protein coding gene Chr11:127768732-127775364 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019841
 protein coding gene Chr11:118938283-118944284 (-)
PWK/PhJ MGP_PWKPhJ_G0018478
 protein coding gene Chr11:115606241-115612880 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018271
 protein coding gene Chr11:118691925-118699598 (-)
WSB/EiJ MGP_WSBEiJ_G0018766
 protein coding gene Chr11:118897320-118904220 (-)



Homology
more
  • Human Ortholog
    H3-3A, H3.3 histone A
  • Vertebrate Orthologs
    9
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    H3-3A, H3.3 histone A
  • Synonyms
    BRYLIB1, H3.3A, H3-3B, H3F3, H3F3A
  • Links
    NCBI Gene ID: 3020
    neXtProt AC: NX_P84243
    UniProt: P84243

  • Chr Location
    1q42.12; chr1:226061831-226072019 (+)  GRCh38
  • Human Ortholog
    H3-3B, H3.3 histone B
  • Synonyms
    BRYLIB2, H3-3A, H3.3B, H3F3B
  • Links
    NCBI Gene ID: 3021
    neXtProt AC: NX_P84243
    UniProt: P84243

  • Chr Location
    17q25.1; chr17:75776434-75785893 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 5 alleles in 5 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for a reporter allele exhibit reduced body size and male infertility due to failure of spermiogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    859
  • Tissues
    57
  • cDNA Data
    59
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000016559 Ensembl Gene Model | MGI Sequence Detail 6051 C57BL/6J ±  kb
    transcript ENSMUST00000016703 Ensembl | MGI Sequence Detail 1993 Not Applicable  
    polypeptide ENSMUSP00000016703 Ensembl | MGI Sequence Detail 136 Not Applicable  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 63
      cDNA 60
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1926214
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 8
      Gene Ontology 7
      Phenotypes 18
    • Earliest
      J:42392 Hraba-Renevey S, et al., Expression of a mouse replacement histone H3.3 gene with a highly conserved 3' noncoding region during SV40- and polyoma-induced Go to S-phase transition. Nucleic Acids Res. 1989 Apr 11;17(7):2449-61
    • Latest
      J:334499 Bush K, et al., A knockout-first model of H3f3a gene targeting leads to developmental lethality. Genesis. 2023 Mar;61(1-2):e23507
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory