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E2f3 Gene Detail
Summary
  • Symbol
    E2f3
  • Name
    E2F transcription factor 3
  • Synonyms
    E2f3a, E2F3b, mKIAA0075
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096340
    NCBI Gene: 13557
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:30090558-30170046 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 13.09 cM, cytoband A3.3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    391 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096340
 protein coding gene Chr13:30090558-30171172 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020411
 protein coding gene Chr13:27747209-27829471 (-)
A/J MGP_AJ_G0020366
 protein coding gene Chr13:27057526-27136638 (-)
AKR/J MGP_AKRJ_G0020343
 protein coding gene Chr13:27621536-27701047 (-)
BALB/cJ MGP_BALBcJ_G0020361
 protein coding gene Chr13:27131331-27216610 (-)
C3H/HeJ MGP_C3HHeJ_G0020164
 protein coding gene Chr13:27653170-27732983 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020797
 protein coding gene Chr13:28690837-28771880 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018388
 protein coding gene Chr13:25475370-25552378 (-)
CAST/EiJ MGP_CASTEiJ_G0019681
 protein coding gene Chr13:27282417-27362756 (-)
CBA/J MGP_CBAJ_G0020120
 protein coding gene Chr13:29938900-30022355 (-)
DBA/2J MGP_DBA2J_G0020242
 protein coding gene Chr13:26589899-26671248 (-)
FVB/NJ MGP_FVBNJ_G0020227
 protein coding gene Chr13:26193031-26273349 (-)
LP/J MGP_LPJ_G0020319
 protein coding gene Chr13:28003041-28082635 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020253
 protein coding gene Chr13:30097927-30190289 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020838
 protein coding gene Chr13:27254683-27334587 (-)
PWK/PhJ MGP_PWKPhJ_G0019436
 protein coding gene Chr13:26730625-26810462 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019257
 protein coding gene Chr13:26177926-26256341 (-)
WSB/EiJ MGP_WSBEiJ_G0019743
 protein coding gene Chr13:27550583-27632352 (-)



Homology
more
  • Human Ortholog
    E2F3, E2F transcription factor 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    E2F3, E2F transcription factor 3
  • Synonyms
    E2F-3
  • Links
    NCBI Gene ID: 1871
    neXtProt AC: NX_O00716
    UniProt: O00716

  • Chr Location
    6p22.3; chr6:20401879-20493714 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human E2F3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 6 alleles in 13 genetic backgrounds
    42 phenotypes from multigenic genotypes
    67 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased lethality prior to adulthood but otherwise appear normal. Mouse embryonic fibroblast cells from mice homozygous for a null allele are defective in cell cycle progression and exhibit reduced proliferation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1041
  • Tissues
    263
  • cDNA Data
    77
  • Literature Summary
    34
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000016477 Ensembl Gene Model | MGI Sequence Detail 79489 C57BL/6J ±  kb
    transcript ENSMUST00000102948 Ensembl | MGI Sequence Detail 5097 Not Applicable  
    polypeptide ENSMUSP00000100012 Ensembl | MGI Sequence Detail 457 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 86
      cDNA 78
      Primer pair 7
      Other 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 151
      Developmental Gene Expression 34
      Gene Ontology 10
      Phenotypes 67
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:331493 Fong BC, et al., The Rb/E2F axis is a key regulator of the molecular signatures instructing the quiescent and activated adult neural stem cell state. Cell Rep. 2022 Nov 1;41(5):111578
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory