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Ywhag Gene Detail
Summary
  • Symbol
    Ywhag
  • Name
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
  • Synonyms
    14-3-3 gamma, D7Bwg1348e
  • Feature Type
    protein coding gene
  • IDs
    MGI:108109
    NCBI Gene: 22628
  • Alliance
    genome feature page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:135937263-135963470 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 75.53 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    832 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108109
 protein coding gene Chr5:135937233-135963495 (-)
129S1/SvImJ ENSMUSG00200043148
 protein coding gene Chr5:129723567-129749756 (-)
A/J ENSMUSG00195044501
 protein coding gene Chr5:129228678-129254773 (-)
AKR/J ENSMUSG00220044596
 protein coding gene Chr5:128724827-128751090 (-)
BALB/cJ ENSMUSG00180043519
 protein coding gene Chr5:129331687-129357775 (-)
C3H/HeJ ENSMUSG00175035707
 protein coding gene Chr5:131259453-131285544 (-)
C57BL/6NJ ENSMUSG00215044898
 protein coding gene Chr5:129378415-129404609 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027846
 protein coding gene Chr5:128754943-128781837 (-)
CAST/EiJ ENSTCUG00005009729
 protein coding gene Chr5:128612451-128638596 (-)
CBA/J ENSMUSG00210007540
 protein coding gene Chr5:130077083-130103177 (-)
DBA/2J ENSMUSG00185051604
 protein coding gene Chr5:133092327-133118420 (-)
FVB/NJ ENSMUSG00205047359
 protein coding gene Chr5:128976715-129002808 (-)
JF1/MsJ ENSUMUG00000050317
 protein coding gene Chr5:135993152-136019360 (-)
LP/J ENSMUSG00230048241
 protein coding gene Chr5:137205906-137231996 (-)
NOD/ShiLtJ ENSMUSG00190042010
 protein coding gene Chr5:129031711-129057800 (-)
NZO/HlLtJ ENSMUSG00225022745
 protein coding gene Chr5:144887539-144913625 (-)
PWK/PhJ ENSLUMG00010014685
 protein coding gene Chr5:127831401-127857598 (-)
SPRET/EiJ ENSMSPG00010032382
 protein coding gene Chr5:131252433-131277622 (-)
WSB/EiJ ENSIUOG00005031456
 protein coding gene Chr5:131679193-131705260 (-)



Homology
more
  • Human Ortholog
    YWHAG, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    YWHAG, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  • Synonyms
    14-3-3GAMMA, DEE56, EIEE56, PPP1R170
  • Links
    NCBI Gene ID: 7532
    UniProt: P61981

  • Chr Location
    7q11.23; chr7:76326799-76358991 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human YWHAG associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    17 phenotype references
Homozygous null mutants appear normal and exhibit unchanged survival rates after inoculation with pathological prion protein.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    76
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    747
  • Tissues
    128
  • cDNA Data
    13
  • Literature Summary
    8
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000051391 Ensembl Gene Model | MGI Sequence Detail 26208 C57BL/6J ±  kb
transcript ENSMUST00000198270 Ensembl | MGI Sequence Detail 1610 Not Applicable  
polypeptide ENSMUSP00000143631 Ensembl | MGI Sequence Detail 247 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 13
    Primer pair 3
    Other 1

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-34146, MGD-MRK-37146, MGI:106452
References
more
  • Summaries
    All 87
    Developmental Gene Expression 8
    Gene Ontology 14
    Phenotypes 17
  • Earliest
    J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
  • Latest
    J:378933 Boulan B, et al., Oriented cell divisions induce basal progenitors and regulate neural expansion across tissues and species. Sci Adv. 2026 Feb 6;12(6):eadz6827
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory