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Fpr1 Gene Detail
Summary
  • Symbol
    Fpr1
  • Name
    formyl peptide receptor 1
  • Synonyms
    fMLF-R, FPR
  • Feature Type
    protein coding gene
  • IDs
    MGI:107443
    NCBI Gene: 14293
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:18096733-18104201 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 10.63 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    282 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107443
 protein coding gene Chr17:18096733-18104202 (-)
129S1/SvImJ ENSMUSG00200036889
 protein coding gene Chr17:13553043-13560514 (-)
A/J ENSMUSG00195035033
 protein coding gene Chr17:14440704-14448174 (-)
AKR/J ENSMUSG00220024173
 protein coding gene Chr17:14094284-14101728 (-)
BALB/cJ ENSMUSG00180014965
 protein coding gene Chr17:13737502-13744972 (-)
C3H/HeJ ENSMUSG00175038004
 protein coding gene Chr17:13584372-13591826 (-)
C57BL/6NJ ENSMUSG00215041551
 protein coding gene Chr17:13560579-13568051 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021106
 protein coding gene Chr17:13375683-13383193 (-)
CAST/EiJ ENSTCUG00005022287
 protein coding gene Chr17:14044399-14051838 (-)
CBA/J ENSMUSG00210030980
 protein coding gene Chr17:13392035-13399488 (-)
DBA/2J ENSMUSG00185034520
 protein coding gene Chr17:15574926-15582398 (-)
FVB/NJ ENSMUSG00205016838
 protein coding gene Chr17:14049655-14057095 (-)
JF1/MsJ ENSUMUG00000034713
 protein coding gene Chr17:15181909-15189312 (-)
LP/J ENSMUSG00230023802
 protein coding gene Chr17:16973126-16980595 (-)
NOD/ShiLtJ ENSMUSG00190036345
 protein coding gene Chr17:13777181-13784650 (-)
NZO/HlLtJ ENSMUSG00225047266
 protein coding gene Chr17:18926778-18934247 (-)
PWK/PhJ ENSLUMG00010017804
 protein coding gene Chr17:13734889-13742307 (-)
SPRET/EiJ ENSMSPG00010032633
 protein coding gene Chr17:15075450-15082950 (-)
WSB/EiJ ENSIUOG00005034462
 protein coding gene Chr17:14411995-14419470 (-)



Homology
more
  • Human Ortholog
    FPR1, formyl peptide receptor 1
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FPR1, formyl peptide receptor 1
  • Synonyms
    FMLP, FPR
  • Links
    NCBI Gene ID: 2357
    UniProt: P21462

  • Chr Location
    19q13.41; chr19:51745172-51804115 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted null mice are viable and developmentally normal but show increased susceptibility to L. monocytogenes challenge, as shown by increased mortality and bacterial burden in liver/spleen early post-infection. Mutant neutrophils fail to respond to fMLF either in calcium flux or chemotaxis assays.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    31
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    606
  • Tissues
    5
  • cDNA Data
    7
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14293 NCBI Gene Model | MGI Sequence Detail 7469 C57BL/6J ±  kb
transcript NM_013521 RefSeq | MGI Sequence Detail 1332 C57BL/6  
polypeptide P33766 UniProt | EBI | MGI Sequence Detail 364 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    Genomic 7
    cDNA 8
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-35914
References
more
  • Summaries
    All 88
    Developmental Gene Expression 2
    Gene Ontology 11
    Phenotypes 45
  • Earliest
    J:43394 Gao JL, et al., Species and subtype variants of the N-formyl peptide chemotactic receptor reveal multiple important functional domains. J Biol Chem. 1993 Dec 5;268(34):25395-401
  • Latest
    J:373019 Chandrasekharan B, et al., Microbiota-dependent Formylated Peptide Receptor (Fpr1/2) Signaling Regulates Enteric Nervous System Development and Gastrointestinal Motility in Mice. Cell Mol Gastroenterol Hepatol. 2025 Sep 2;:101624
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory