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Alk Gene Detail
Summary
  • Symbol
    Alk
  • Name
    anaplastic lymphoma kinase
  • Synonyms
    CD246, Tcrz
  • Feature Type
    protein coding gene
  • IDs
    MGI:103305
    NCBI Gene: 11682
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:72175967-72911622 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 43.77 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    22390 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103305
 protein coding gene Chr17:72174206-72911719 (-)
129S1/SvImJ ENSMUSG00200038260
 protein coding gene Chr17:67452290-68183458 (-)
A/J ENSMUSG00195017569
 protein coding gene Chr17:68861364-69591035 (-)
AKR/J ENSMUSG00220017245
 protein coding gene Chr17:67902999-68636292 (-)
BALB/cJ ENSMUSG00180019391
 protein coding gene Chr17:68597518-69336131 (-)
C3H/HeJ ENSMUSG00175028028
 protein coding gene Chr17:67853190-68595403 (-)
C57BL/6NJ ENSMUSG00215014055
 protein coding gene Chr17:67592180-68327753 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021865
 protein coding gene Chr17:67841714-68558250 (-)
CAST/EiJ ENSTCUG00005024806
 protein coding gene Chr17:68443804-69162530 (-)
CBA/J ENSMUSG00210027381
 protein coding gene Chr17:67723008-68465219 (-)
DBA/2J ENSMUSG00185021685
 protein coding gene Chr17:70555999-71298244 (-)
FVB/NJ ENSMUSG00205015822
 protein coding gene Chr17:68367450-69099456 (-)
JF1/MsJ ENSUMUG00000033212
 protein coding gene Chr17:70225141-70944453 (-)
LP/J ENSMUSG00230015229
 protein coding gene Chr17:71512393-72243494 (-)
NOD/ShiLtJ ENSMUSG00190028843
 protein coding gene Chr17:67603279-68346214 (-)
NZO/HlLtJ ENSMUSG00225028756
 protein coding gene Chr17:73794848-74540746 (-)
PWK/PhJ ENSLUMG00010025919
 protein coding gene Chr17:67454131-68173633 (-)
SPRET/EiJ ENSMSPG00010016892
 protein coding gene Chr17:67801885-68517489 (-)
WSB/EiJ ENSIUOG00005031917
 protein coding gene Chr17:68574905-69312290 (-)



Homology
more
  • Human Ortholog
    ALK, ALK receptor tyrosine kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALK, ALK receptor tyrosine kinase
  • Synonyms
    ALK1, CD246, NBLST3
  • Links
    NCBI Gene ID: 238
    UniProt: Q9UM73

  • Chr Location
    2p23.2-p23.1; chr2:29192774-29921586 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Alk mouse models; 1 with human ALK associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    42 phenotypes from 4 alleles in 4 genetic backgrounds
    9 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show increased ethanol consumption and increased sedation in response to ethanol. Male mice homozygous for a different null allele show delayed puberty, hypogonadotropic hypogonadism, reduced serum testosterone levels, and altered seminiferous tubule morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1144
  • Tissues
    372
  • cDNA Data
    20
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000055471 Ensembl Gene Model | MGI Sequence Detail 735656 C57BL/6J ±  kb
    transcript ENSMUST00000086639 Ensembl | MGI Sequence Detail 5454 Not Applicable  
    polypeptide ENSMUSP00000083840 Ensembl | MGI Sequence Detail 1621 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000001282 ALK tyrosine kinase receptor
      (term hierarchy)
    • EC
      2.7.10.1
    • InterPro Domains
      IPR055163 ALK/LTK-like, glycine-rich domain
      IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
      IPR036055 LDL receptor-like superfamily
      IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
      IPR000998 MAM domain
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR050122 Receptor Tyrosine Kinase
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR008266 Tyrosine-protein kinase, active site
      IPR020635 Tyrosine-protein kinase, catalytic domain
      IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
    • GlyGen
      P97793 19 sites, 5 N-linked glycans (5 sites)
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 3
      cDNA 20
      Primer pair 2
      Other 1
      Antibodies 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-24189
    References
    more
    • Summaries
      All 110
      Developmental Gene Expression 14
      Diseases 4
      Gene Ontology 17
      Phenotypes 24
    • Earliest
      J:38791 Fujita N, et al., Developmentally regulated alternative splicing of brain myelin-associated glycoprotein mRNA is lacking in the quaking mouse. FEBS Lett. 1988 May 23;232(2):323-7
    • Latest
      J:385781 Tang T, et al., Ribosomal Profiling of the Geniculate Ganglion Identifies the Receptor ALK as Critical for the Development and Maintenance of Oral Sensory Neurons. J Neurosci. 2026 Apr 8;46(14)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory