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Ednrb Gene Detail
Summary
  • Symbol
    Ednrb
  • Name
    endothelin receptor type B
  • Synonyms
    ETb, ETR-b, Sox10m1
  • Feature Type
    protein coding gene
  • IDs
    MGI:102720
    NCBI Gene: 13618
  • Alliance
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:104052055-104081764 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 14, 53.05 cM
  • Mapping Data
    30 experiments
Strain
Comparison
more
  • SNPs within 2kb
    877 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102720
protein coding gene Chr14:104052055-104081838 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021633
protein coding gene Chr14:100342866-100372062 (-)
A/J MGP_AJ_G0021591
protein coding gene Chr14:97007734-97037147 (-)
AKR/J MGP_AKRJ_G0021567
protein coding gene Chr14:99932324-99961669 (-)
BALB/cJ MGP_BALBcJ_G0021597
protein coding gene Chr14:97368258-97398281 (-)
C3H/HeJ MGP_C3HHeJ_G0021375
protein coding gene Chr14:99816948-99849850 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022037
protein coding gene Chr14:104372554-104403009 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019577
protein coding gene Chr14:93868863-93898105 (-)
CAST/EiJ MGP_CASTEiJ_G0020892
protein coding gene Chr14:97157703-97189122 (-)
CBA/J MGP_CBAJ_G0021343
protein coding gene Chr14:108133205-108169173 (-)
DBA/2J MGP_DBA2J_G0021467
protein coding gene Chr14:96501370-96543893 (-)
FVB/NJ MGP_FVBNJ_G0021444
protein coding gene Chr14:95479337-95508870 (-)
LP/J MGP_LPJ_G0021535
protein coding gene Chr14:101159460-101189078 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021471
protein coding gene Chr14:110989772-111021924 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022060
protein coding gene Chr14:99444325-99473703 (-)
PWK/PhJ MGP_PWKPhJ_G0020635
protein coding gene Chr14:93503879-93534161 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020473
protein coding gene Chr14:95489039-95520499 (-)
WSB/EiJ MGP_WSBEiJ_G0020945
protein coding gene Chr14:100100307-100131358 (-)



Homology
more
  • Human Ortholog
    EDNRB, endothelin receptor type B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EDNRB, endothelin receptor type B
  • Synonyms
    ABCDS, ET-B, ETB, ETB1, ET-BR, ETBR, ETRB, HSCR, HSCR2, WS4A
  • Links
    NCBI Gene ID: 1910
    neXtProt AC: NX_P24530
    UniProt: P24530

  • Chr Location
    13q22.3; chr13:77895481-77975529 (-)  GRCh38

Human Diseases
more
  • Diseases
    2 with Ednrb mouse models; 5 with human EDNRB associations

Human Disease Mouse Models
      
IDs
View 5 models
IDs
View 2 models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    102 phenotypes from 46 alleles in 23 genetic backgrounds
    59 phenotypes from multigenic genotypes
    16 images
    135 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null mutations have pigmentation limited to small patches on the head and rump and die from megacolon resulting from impaired neural crest migration and aganglionosis. Heterozygotes for a null allele show improved cardiac tolerance to hypoxia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13618 NCBI Gene Model | MGI Sequence Detail 29710 C57BL/6J ±  kb
    transcript NM_001136061 RefSeq | MGI Sequence Detail 4039 ZRU/MplStud  
    polypeptide P48302 UniProt | EBI | MGI Sequence Detail 442 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 140
      Genomic 1
      cDNA 127
      Primer pair 9
      Other 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-14268, MGD-MRK-19624, MGI:2145744
    References
    more
    • Summaries
      All 266
      Developmental Gene Expression 60
      Diseases 7
      Gene Ontology 21
      Phenotypes 135
    • Earliest
      J:23183 Dunn LC, Types of white spotting in mice. Am Naturalist. 1920 Nov-Dec;54:465-95
    • Latest
      J:353730 Wang CH, et al., Endothelin 3/EDNRB signaling induces thermogenic differentiation of white adipose tissue. Nat Commun. 2024 Aug 22;15(1):7215

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    10/22/2024
    MGI 6.24
    The Jackson Laboratory