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p-alpha-DO Probe Detail
Nucleotide
Probe/Clone
  • Name
    p-alpha-DO
  • Sequence Type
    cDNA
  • ID
    MGI:13432
  • Region Covered
    encodes gene segments Tcra-V13.1, Tcra-J, Tcra-C and 3' untranslated sequence
  • Vector Type
    Plasmid
  • Insert Site
    Hind/EcoRI
  • Insert Size
    1.2 kb
Source
  • Species
    mouse, laboratory
  • Tissue
    T-lymphocyte
  • Cell Line
    hybridoma cell line DP.11.10
Genes
Tcra-J T cell receptor alpha, joining region
Trav5-4 T cell receptor alpha variable 5-4
Trac T cell receptor alpha constant
Polymorphisms
J:8208 Epstein R, et al., J Exp Med. 1986 Apr 1;163(4):759-73
Notes: A 475 bp HindIII/RsaI fragment specific for Tcra-V13 was isolated from p[a]DO and used in Southern analysis.
Endonuclease Gene Allele Fragments Strains
BglI Trav5-4 c not given SJL/J
j not given BALB/cKe, SJL/J
EcoRI Trav5-4 c 3.3,1.0kb SJL/J
j 0.7kb BALB/cKe, SJL/J
KpnI Trav5-4 c not given SJL/J
j not given BALB/cKe, SJL/J
References
J:7926 Yague J, et al., The T cell receptor: the alpha and beta chains define idiotype, and antigen and MHC specificity. Cell. 1985 Aug;42(1):81-7
J:8208 Epstein R, et al., The cytotoxic T cell response to the male-specific histocompatibility antigen (H-Y) is controlled by two dominant immune response genes, one in the MHC, the other in the Tar alpha-locus. J Exp Med. 1986 Apr 1;163(4):759-73
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/14/2024
MGI 6.23 		The Jackson Laboratory