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Tcra-J Complex/Cluster/Region Detail
Summary
  • Symbol
    Tcra-J
  • Name
    T cell receptor alpha, joining region
  • Synonyms
    Jalpha281
  • Feature Type
    complex/cluster/region
  • IDs
    MGI:98555
    NCBI Gene: 21475
Location &
Maps
more
  • Sequence Map
    Genome coordinates not available from the current reference assembly.
  • Genetic Map
    Chromosome 14, Syntenic
  • Mapping Data
    1 experiment
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    44 phenotypes from 7 alleles in 8 genetic backgrounds
    10 phenotypes from multigenic genotypes
    1 images
    328 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes with mutations in this locus have aberrant recombination of the Tcra gene segments that affects expression of the T-cell receptor.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    1
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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  • Literature Summary
    1
  • Other Mouse Links
    GEO
Sequences &
Gene Models
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  • All Sequences
    3
Representative SequencesLengthStrain/SpeciesFlank
genomic M38099 GenBank | ENA | DDBJ | MGI Sequence Detail 701 B10.BR-H2 H2-T18/SgSnJ ±  kb
For the selected sequence
Molecular
Reagents
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  • All nucleic 131
    Genomic 57
    cDNA 69
    Other 5
Other
Accession IDs
less
MGD-MRK-14847
References
more
  • Summaries
    All 363
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 1
    Phenotypes 328
  • Earliest
    J:7626 Chien Y, et al., A third type of murine T-cell receptor gene. Nature. 1984 Nov 1-7;312(5989):31-5
  • Latest
    J:346308 Robin A, et al., Early activation and recruitment of invariant natural killer T cells during liver ischemia-reperfusion: the major role of the alarmin interleukin-33. Front Immunol. 2023;14:1099529
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory