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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Abca1
ATP-binding cassette, sub-family A member 1
MGI:99607
64 phenotypes from 8 alleles in 15 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Abca1m4620Dajl/Abca1+
involves: C3H/HeSnJ * C57BL/6J * SWR 		decreased circulating cholesterol level J:149088
decreased circulating HDL cholesterol level J:149088
Abca1m4620Dajl/Abca1m4620Dajl
involves: C3H/HeSnJ * C57BL/6J * SWR 		decreased circulating cholesterol level J:149088
decreased circulating HDL cholesterol level J:149088
increased circulating triglyceride level J:149088
Abca1mpc227H/Abca1mpc227H
involves: BALB/c * C3H/HeH * C57BL/6J 		decreased circulating cholesterol level J:234901
Abca1tm1.1Jp/Abca1tm1.1Jp
involves: 129S6/SvEvTac * C57BL/6 		abnormal circulating phospholipid level J:98093
decreased circulating cholesterol level J:98093
decreased circulating HDL cholesterol level J:98093
Abca1tm1b(EUCOMM)Hmgu/Abca1+
C57BL/6N-Abca1tm1b(EUCOMM)Hmgu/Bay 		abnormal retina morphology J:211773
unresponsive to tactile stimuli J:211773
Abca1tm1b(EUCOMM)Hmgu/Abca1tm1b(EUCOMM)Hmgu
C57BL/6N-Abca1tm1b(EUCOMM)Hmgu/Bay 		abnormal embryo size J:211773
preweaning lethality, complete penetrance J:211773
unresponsive to tactile stimuli J:211773
Abca1tm1Blt/Abca1tm1Blt
C57BL/6-Abca1tm1Blt 		abnormal platelet physiology J:95088
Abca1tm1Jdm/Abca1+
DBA/1LacJ-Abca1tm1Jdm 		abnormal circulating phospholipid level J:61679
abnormal lipid homeostasis J:61679
abnormal lung morphology J:61679
decreased circulating cholesterol level J:61679
decreased circulating HDL cholesterol level J:61679
decreased circulating LDL cholesterol level J:61679
Abca1tm1Jdm/Abca1tm1Jdm
DBA/1-Abca1tm1Jdm/J 		increased cholesterol efflux J:130777
Abca1tm1Jdm/Abca1tm1Jdm
DBA/1LacJ-Abca1tm1Jdm 		abnormal circulating phospholipid level J:61679
abnormal fat-soluble vitamin level J:60210
abnormal lipid homeostasis J:61679
abnormal lung morphology J:61679
abnormal placenta development J:63265
abnormal pulmonary alveolus morphology J:61679
decreased body weight J:60210
decreased circulating cholesterol level J:60210, J:61679
decreased circulating HDL cholesterol level J:60210, J:61679
decreased circulating LDL cholesterol level J:61679
enlarged adrenal glands J:60210
enlarged spleen J:60210
female infertility J:63265
hemorrhage J:63265
impaired macrophage phagocytosis J:63265
increased intestinal cholesterol absorption J:61679
perinatal lethality, incomplete penetrance J:61679
postnatal lethality, incomplete penetrance J:63265
thrombocytopenia J:60210
Abca1tm1Jdm/Abca1tm1Jdm
involves: C57BL/6 * DBA/1LacJ 		abnormal thymus morphology J:132254
decreased circulating cholesterol level J:132254
decreased circulating HDL cholesterol level J:132254
normal homeostasis/metabolism phenotype J:132254
impaired macrophage phagocytosis J:132254
perinatal lethality, incomplete penetrance J:132254
Abca1tm1Jdm/Abca1tm1Jdm
involves: DBA/1LacJ 		abnormal cholesterol homeostasis J:89906
abnormal Leydig cell morphology J:89906
abnormal seminiferous tubule epithelium morphology J:89906
abnormal seminiferous tubule morphology J:89906
abnormal Sertoli cell morphology J:89906
abnormal testosterone level J:89906
decreased cholesterol efflux J:89906
decreased circulating HDL cholesterol level J:89906
decreased circulating phytosterol level J:87209
oligozoospermia J:89906
reduced male fertility J:89906
seminiferous tubule degeneration J:89906
Abca1tm1Jp/Abca1+
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S6/SvEvTac * B6.Cg-Tg(Alb-cre)21Mgn/J 		abnormal cholesterol homeostasis J:98093
abnormal circulating phospholipid level J:98093
decreased circulating cholesterol level J:98093
decreased circulating HDL cholesterol level J:98093
Abca1tm1Jp/Abca1+
Tg(Vil1-cre)997Gum/0
involves: 129S6/SvEvTac * C57BL/6 * SJL 		decreased circulating cholesterol level J:107802
decreased circulating HDL cholesterol level J:107802
Abca1tm1Jp/Abca1tm1Jp
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S6/SvEvTac * B6.Cg-Tg(Alb-cre)21Mgn/J 		abnormal cholesterol homeostasis J:98093
abnormal circulating phospholipid level J:98093
decreased circulating cholesterol level J:98093
decreased circulating HDL cholesterol level J:98093
decreased circulating LDL cholesterol level J:98093
increased circulating triglyceride level J:98093
Abca1tm1Jp/Abca1tm1Jp
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S6/SvEvTac * C57BL/6 * DBA 		decreased circulating HDL cholesterol level J:107802
Abca1tm1Jp/Abca1tm1Jp
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Tg(Vil1-cre)997Gum/0
involves: 129S6/SvEvTac * C57BL/6 * DBA * SJL 		decreased circulating HDL cholesterol level J:107802
Abca1tm1Jp/Abca1tm1Jp
Tg(Vil1-cre)997Gum/0
involves: 129S6/SvEvTac * C57BL/6 * SJL 		abnormal enterocyte physiology J:107802
decreased cholesterol efflux J:107802
decreased circulating cholesterol level J:107802
decreased circulating HDL cholesterol level J:107802
decreased circulating LDL cholesterol level J:107802
Abca1tm1Wpfl/Abca1+
involves: 129P2/OlaHsd * C57BL/6J 		abnormal placenta labyrinth morphology J:64390
cardiomyopathy J:64390
decreased circulating cholesterol level J:64390
decreased circulating HDL cholesterol level J:64390
heart left ventricle hypertrophy J:64390
heart right ventricle hypertrophy J:64390
lung hemorrhage J:64390
reduced female fertility J:64390
respiratory distress J:64390
Abca1tm1Wpfl/Abca1tm1Wpfl
involves: 129 * C57BL/6 		abnormal Sertoli cell morphology J:101966
Abca1tm1Wpfl/Abca1tm1Wpfl
involves: 129P2/OlaHsd * C57BL/6J 		abnormal adrenal gland morphology J:64390
abnormal kidney cortex morphology J:64390
abnormal ovary morphology J:64390
abnormal placenta labyrinth morphology J:64390
abnormal Sertoli cell morphology J:64390
abnormal thymus morphology J:64390
abnormal uterus morphology J:64390
cardiomyopathy J:64390
decreased body size J:64390
decreased circulating cholesterol level J:64390, J:68431
decreased circulating estradiol level J:64390
decreased circulating HDL cholesterol level J:64390, J:68431
decreased circulating progesterone level J:64390
decreased intestinal cholesterol absorption J:68431
embryonic growth arrest J:64390
embryonic growth retardation J:64390
glomerulonephritis J:64390
glomerulosclerosis J:64390
heart left ventricle hypertrophy J:64390
heart right ventricle hypertrophy J:64390
lethality throughout fetal growth and development, incomplete penetrance J:64390
lung hemorrhage J:64390
macrovesicular hepatic steatosis J:64390
placenta hemorrhage J:64390
postnatal lethality, incomplete penetrance J:64390
reduced female fertility J:64390
renal glomerular immunoglobulin deposits J:64390
respiratory distress J:64390
uterus inflammation J:64390
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/09/2024
MGI 6.23 		The Jackson Laboratory