About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Abca1
ATP-binding cassette, sub-family A member 1
MGI:99607
74 phenotypes from 9 alleles in 16 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
\Abca1m4620Dajl/\Abca1+
involves: C3H/HeSnJ * C57BL/6J * SWR 		decreased circulating cholesterol level J:149088
decreased circulating HDL cholesterol level J:149088
\Abca1m4620Dajl/\Abca1m4620Dajl
involves: C3H/HeSnJ * C57BL/6J * SWR 		decreased circulating cholesterol level J:149088
decreased circulating HDL cholesterol level J:149088
increased circulating triglyceride level J:149088
\Abca1mpc227H/\Abca1mpc227H
involves: BALB/c * C3H/HeH * C57BL/6J 		decreased circulating cholesterol level J:234901
\Abca1tm1.1Jp/\Abca1tm1.1Jp
involves: 129S6/SvEvTac * C57BL/6 		abnormal circulating phospholipid level J:98093
decreased circulating cholesterol level J:98093
decreased circulating HDL cholesterol level J:98093
\Abca1tm1b(EUCOMM)Hmgu/\Abca1+
C57BL/6N-Abca1tm1b(EUCOMM)Hmgu/Bay 		abnormal retina morphology J:211773
unresponsive to tactile stimuli J:211773
\Abca1tm1b(EUCOMM)Hmgu/\Abca1tm1b(EUCOMM)Hmgu
C57BL/6N-Abca1tm1b(EUCOMM)Hmgu/Bay 		abnormal embryo size J:211773
preweaning lethality, complete penetrance J:211773
unresponsive to tactile stimuli J:211773
\Abca1tm1Blt/\Abca1tm1Blt
C57BL/6-Abca1tm1Blt 		abnormal platelet physiology J:95088
\Abca1tm1Jdm/\Abca1+
DBA/1LacJ-Abca1tm1Jdm 		abnormal circulating phospholipid level J:61679
abnormal lipid homeostasis J:61679
abnormal lung morphology J:61679
decreased circulating cholesterol level J:61679
decreased circulating HDL cholesterol level J:61679
decreased circulating LDL cholesterol level J:61679
\Abca1tm1Jdm/\Abca1tm1Jdm
DBA/1-Abca1tm1Jdm/J 		increased cholesterol efflux J:130777
\Abca1tm1Jdm/\Abca1tm1Jdm
DBA/1LacJ-Abca1tm1Jdm 		abnormal circulating phospholipid level J:61679
abnormal fat-soluble vitamin level J:60210
abnormal lipid homeostasis J:61679
abnormal lung morphology J:61679
abnormal placenta development J:63265
abnormal pulmonary alveolus morphology J:61679
decreased body weight J:60210
decreased circulating cholesterol level J:60210, J:61679
decreased circulating HDL cholesterol level J:60210, J:61679
decreased circulating LDL cholesterol level J:61679
enlarged adrenal glands J:60210
enlarged spleen J:60210
female infertility J:63265
hemorrhage J:63265
impaired macrophage phagocytosis J:63265
increased intestinal cholesterol absorption J:61679
perinatal lethality, incomplete penetrance J:61679
postnatal lethality, incomplete penetrance J:63265
thrombocytopenia J:60210
\Abca1tm1Jdm/\Abca1tm1Jdm
involves: C57BL/6 * DBA/1LacJ 		abnormal thymus morphology J:132254
decreased circulating cholesterol level J:132254
decreased circulating HDL cholesterol level J:132254
normal homeostasis/metabolism phenotype J:132254
impaired macrophage phagocytosis J:132254
perinatal lethality, incomplete penetrance J:132254
\Abca1tm1Jdm/\Abca1tm1Jdm
involves: DBA/1LacJ 		abnormal cholesterol homeostasis J:89906
abnormal Leydig cell morphology J:89906
abnormal seminiferous tubule epithelium morphology J:89906
abnormal seminiferous tubule morphology J:89906
abnormal Sertoli cell morphology J:89906
abnormal testosterone level J:89906
decreased cholesterol efflux J:89906
decreased circulating HDL cholesterol level J:89906
decreased circulating phytosterol level J:87209
oligozoospermia J:89906
reduced male fertility J:89906
seminiferous tubule degeneration J:89906
\Abca1tm1Jp/\Abca1+
\Speer6-ps1Tg(Alb-cre)21Mgn/\Speer6-ps1+
involves: 129S6/SvEvTac * B6.Cg-Tg(Alb-cre)21Mgn/J 		abnormal cholesterol homeostasis J:98093
abnormal circulating phospholipid level J:98093
decreased circulating cholesterol level J:98093
decreased circulating HDL cholesterol level J:98093
\Abca1tm1Jp/\Abca1+
\Tg(Vil1-cre)997Gum/0
involves: 129S6/SvEvTac * C57BL/6 * SJL 		decreased circulating cholesterol level J:107802
decreased circulating HDL cholesterol level J:107802
\Abca1tm1Jp/\Abca1tm1Jp
\Speer6-ps1Tg(Alb-cre)21Mgn/\Speer6-ps1+
involves: 129S6/SvEvTac * B6.Cg-Tg(Alb-cre)21Mgn/J 		abnormal cholesterol homeostasis J:98093
abnormal circulating phospholipid level J:98093
decreased circulating cholesterol level J:98093
decreased circulating HDL cholesterol level J:98093
decreased circulating LDL cholesterol level J:98093
increased circulating triglyceride level J:98093
\Abca1tm1Jp/\Abca1tm1Jp
\Speer6-ps1Tg(Alb-cre)21Mgn/\Speer6-ps1+
involves: 129S6/SvEvTac * C57BL/6 * DBA 		decreased circulating HDL cholesterol level J:107802
\Abca1tm1Jp/\Abca1tm1Jp
\Speer6-ps1Tg(Alb-cre)21Mgn/\Speer6-ps1+
\Tg(Vil1-cre)997Gum/0
involves: 129S6/SvEvTac * C57BL/6 * DBA * SJL 		decreased circulating HDL cholesterol level J:107802
\Abca1tm1Jp/\Abca1tm1Jp
\Tg(Vil1-cre)997Gum/0
involves: 129S6/SvEvTac * C57BL/6 * SJL 		abnormal enterocyte physiology J:107802
decreased cholesterol efflux J:107802
decreased circulating cholesterol level J:107802
decreased circulating HDL cholesterol level J:107802
decreased circulating LDL cholesterol level J:107802
\Abca1tm1Wpfl/\Abca1+
involves: 129P2/OlaHsd * C57BL/6J 		abnormal placenta labyrinth morphology J:64390
cardiomyopathy J:64390
decreased circulating cholesterol level J:64390
decreased circulating HDL cholesterol level J:64390
heart left ventricle hypertrophy J:64390
heart right ventricle hypertrophy J:64390
lung hemorrhage J:64390
reduced female fertility J:64390
respiratory distress J:64390
\Abca1tm1Wpfl/\Abca1tm1Wpfl
involves: 129 * C57BL/6 		abnormal Sertoli cell morphology J:101966
\Abca1tm1Wpfl/\Abca1tm1Wpfl
involves: 129P2/OlaHsd * C57BL/6J 		abnormal adrenal gland morphology J:64390
abnormal kidney cortex morphology J:64390
abnormal ovary morphology J:64390
abnormal placenta labyrinth morphology J:64390
abnormal Sertoli cell morphology J:64390
abnormal thymus morphology J:64390
abnormal uterus morphology J:64390
cardiomyopathy J:64390
decreased body size J:64390
decreased circulating cholesterol level J:64390, J:68431
decreased circulating estradiol level J:64390
decreased circulating HDL cholesterol level J:64390, J:68431
decreased circulating progesterone level J:64390
decreased intestinal cholesterol absorption J:68431
embryonic growth arrest J:64390
embryonic growth retardation J:64390
glomerulonephritis J:64390
glomerulosclerosis J:64390
heart left ventricle hypertrophy J:64390
heart right ventricle hypertrophy J:64390
lethality throughout fetal growth and development, incomplete penetrance J:64390
lung hemorrhage J:64390
macrovesicular hepatic steatosis J:64390
placenta hemorrhage J:64390
postnatal lethality, incomplete penetrance J:64390
reduced female fertility J:64390
renal glomerular immunoglobulin deposits J:64390
respiratory distress J:64390
uterus inflammation J:64390
\Tg(Prnp-Abca1)EHol/0
involves: C57BL/6 * CBA 		abnormal glial cell physiology J:131400
abnormal protein level J:131400
abnormal spermatogenesis J:131400
abnormal testis development J:131400
abnormal testis morphology J:131400
amyloid beta deposits J:131400
decreased testis weight J:131400
normal homeostasis/metabolism phenotype J:131400
male infertility J:131400
multinucleated giant male germ cells J:131400
seminiferous tubule degeneration J:131400
testicular atrophy J:131400
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory