Abca1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Abca1
ATP-binding cassette, sub-family A member 1
MGI:99607

74 phenotypes from 9 alleles in 16 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Abca1^m4620Dajl/Abca1⁺ involves: C3H/HeSnJ * C57BL/6J * SWR	decreased circulating cholesterol level	J:149088
Abca1^m4620Dajl/Abca1⁺ involves: C3H/HeSnJ * C57BL/6J * SWR	decreased circulating HDL cholesterol level	J:149088
Abca1^m4620Dajl/Abca1^m4620Dajl involves: C3H/HeSnJ * C57BL/6J * SWR	decreased circulating cholesterol level	J:149088
	decreased circulating HDL cholesterol level	J:149088
	increased circulating triglyceride level	J:149088
Abca1^mpc227H/Abca1^mpc227H involves: BALB/c * C3H/HeH * C57BL/6J	decreased circulating cholesterol level	J:234901
Abca1^tm1.1Jp/Abca1^tm1.1Jp involves: 129S6/SvEvTac * C57BL/6	abnormal circulating phospholipid level	J:98093
	decreased circulating cholesterol level	J:98093
	decreased circulating HDL cholesterol level	J:98093
Abca1^{tm1b(EUCOMM)Hmgu}/Abca1⁺ C57BL/6N-Abca1^{tm1b(EUCOMM)Hmgu}/Bay	abnormal retina morphology	J:211773
	unresponsive to tactile stimuli	J:211773
Abca1^{tm1b(EUCOMM)Hmgu}/Abca1^{tm1b(EUCOMM)Hmgu} C57BL/6N-Abca1^{tm1b(EUCOMM)Hmgu}/Bay	abnormal embryo size	J:211773
	preweaning lethality, complete penetrance	J:211773
	unresponsive to tactile stimuli	J:211773
Abca1^tm1Blt/Abca1^tm1Blt C57BL/6-Abca1^tm1Blt	abnormal platelet physiology	J:95088
Abca1^tm1Jdm/Abca1⁺ DBA/1LacJ-Abca1^tm1Jdm	abnormal circulating phospholipid level	J:61679
	abnormal lipid homeostasis	J:61679
	abnormal lung morphology	J:61679
	decreased circulating cholesterol level	J:61679
	decreased circulating HDL cholesterol level	J:61679
	decreased circulating LDL cholesterol level	J:61679
Abca1^tm1Jdm/Abca1^tm1Jdm DBA/1-Abca1^tm1Jdm/J	increased cholesterol efflux	J:130777
Abca1^tm1Jdm/Abca1^tm1Jdm DBA/1LacJ-Abca1^tm1Jdm	abnormal circulating phospholipid level	J:61679
	abnormal fat-soluble vitamin level	J:60210
	abnormal lipid homeostasis	J:61679
	abnormal lung morphology	J:61679
	abnormal placenta development	J:63265
	abnormal pulmonary alveolus morphology	J:61679
	decreased body weight	J:60210
	decreased circulating cholesterol level	J:60210, J:61679
	decreased circulating HDL cholesterol level	J:60210, J:61679
	decreased circulating LDL cholesterol level	J:61679
	enlarged adrenal glands	J:60210
	enlarged spleen	J:60210
	female infertility	J:63265
	hemorrhage	J:63265
	impaired macrophage phagocytosis	J:63265
	increased intestinal cholesterol absorption	J:61679
	perinatal lethality, incomplete penetrance	J:61679
	postnatal lethality, incomplete penetrance	J:63265
	thrombocytopenia	J:60210
Abca1^tm1Jdm/Abca1^tm1Jdm involves: C57BL/6 * DBA/1LacJ	abnormal thymus morphology	J:132254
	decreased circulating cholesterol level	J:132254
	decreased circulating HDL cholesterol level	J:132254
	normal homeostasis/metabolism phenotype	J:132254
	impaired macrophage phagocytosis	J:132254
	perinatal lethality, incomplete penetrance	J:132254
Abca1^tm1Jdm/Abca1^tm1Jdm involves: DBA/1LacJ	abnormal cholesterol homeostasis	J:89906
	abnormal Leydig cell morphology	J:89906
	abnormal seminiferous tubule epithelium morphology	J:89906
	abnormal seminiferous tubule morphology	J:89906
	abnormal Sertoli cell morphology	J:89906
	abnormal testosterone level	J:89906
	decreased cholesterol efflux	J:89906
	decreased circulating HDL cholesterol level	J:89906
	decreased circulating phytosterol level	J:87209
	oligozoospermia	J:89906
	reduced male fertility	J:89906
	seminiferous tubule degeneration	J:89906
Abca1^tm1Jp/Abca1⁺ Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S6/SvEvTac * B6.Cg-Tg(Alb-cre)21Mgn/J	abnormal cholesterol homeostasis	J:98093
	abnormal circulating phospholipid level	J:98093
	decreased circulating cholesterol level	J:98093
	decreased circulating HDL cholesterol level	J:98093
Abca1^tm1Jp/Abca1⁺ Tg(Vil1-cre)997Gum/0 involves: 129S6/SvEvTac * C57BL/6 * SJL	decreased circulating cholesterol level	J:107802
	decreased circulating HDL cholesterol level	J:107802
Abca1^tm1Jp/Abca1^tm1Jp Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S6/SvEvTac * B6.Cg-Tg(Alb-cre)21Mgn/J	abnormal cholesterol homeostasis	J:98093
	abnormal circulating phospholipid level	J:98093
	decreased circulating cholesterol level	J:98093
	decreased circulating HDL cholesterol level	J:98093
	decreased circulating LDL cholesterol level	J:98093
	increased circulating triglyceride level	J:98093
Abca1^tm1Jp/Abca1^tm1Jp Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S6/SvEvTac * C57BL/6 * DBA	decreased circulating HDL cholesterol level	J:107802
Abca1^tm1Jp/Abca1^tm1Jp Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Tg(Vil1-cre)997Gum/0 involves: 129S6/SvEvTac * C57BL/6 * DBA * SJL	decreased circulating HDL cholesterol level	J:107802
Abca1^tm1Jp/Abca1^tm1Jp Tg(Vil1-cre)997Gum/0 involves: 129S6/SvEvTac * C57BL/6 * SJL	abnormal enterocyte physiology	J:107802
	decreased cholesterol efflux	J:107802
	decreased circulating cholesterol level	J:107802
	decreased circulating HDL cholesterol level	J:107802
	decreased circulating LDL cholesterol level	J:107802
Abca1^tm1Wpfl/Abca1⁺ involves: 129P2/OlaHsd * C57BL/6J	abnormal placenta labyrinth morphology	J:64390
	cardiomyopathy	J:64390
	decreased circulating cholesterol level	J:64390
	decreased circulating HDL cholesterol level	J:64390
	heart left ventricle hypertrophy	J:64390
	heart right ventricle hypertrophy	J:64390
	lung hemorrhage	J:64390
	reduced female fertility	J:64390
	respiratory distress	J:64390
Abca1^tm1Wpfl/Abca1^tm1Wpfl involves: 129 * C57BL/6	abnormal Sertoli cell morphology	J:101966
Abca1^tm1Wpfl/Abca1^tm1Wpfl involves: 129P2/OlaHsd * C57BL/6J	abnormal adrenal gland morphology	J:64390
	abnormal kidney cortex morphology	J:64390
	abnormal ovary morphology	J:64390
	abnormal placenta labyrinth morphology	J:64390
	abnormal Sertoli cell morphology	J:64390
	abnormal thymus morphology	J:64390
	abnormal uterus morphology	J:64390
	cardiomyopathy	J:64390
	decreased body size	J:64390
	decreased circulating cholesterol level	J:64390, J:68431
	decreased circulating estradiol level	J:64390
	decreased circulating HDL cholesterol level	J:64390, J:68431
	decreased circulating progesterone level	J:64390
	decreased intestinal cholesterol absorption	J:68431
	embryonic growth arrest	J:64390
	embryonic growth retardation	J:64390
	glomerulonephritis	J:64390
	glomerulosclerosis	J:64390
	heart left ventricle hypertrophy	J:64390
	heart right ventricle hypertrophy	J:64390
	lethality throughout fetal growth and development, incomplete penetrance	J:64390
	lung hemorrhage	J:64390
	macrovesicular hepatic steatosis	J:64390
	placenta hemorrhage	J:64390
	postnatal lethality, incomplete penetrance	J:64390
	reduced female fertility	J:64390
	renal glomerular immunoglobulin deposits	J:64390
	respiratory distress	J:64390
	uterus inflammation	J:64390
Tg(Prnp-Abca1)EHol/0 involves: C57BL/6 * CBA	abnormal glial cell physiology	J:131400
	abnormal protein level	J:131400
	abnormal spermatogenesis	J:131400
	abnormal testis development	J:131400
	abnormal testis morphology	J:131400
	amyloid beta deposits	J:131400
	decreased testis weight	J:131400
	normal homeostasis/metabolism phenotype	J:131400
	male infertility	J:131400
	multinucleated giant male germ cells	J:131400
	seminiferous tubule degeneration	J:131400
	testicular atrophy	J:131400

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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