Ppa1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ppa1
pyrophosphatase (inorganic) 1
MGI:97831

34 phenotypes from 1 allele in 1 genetic background

Allelic Composition Genetic Background	Annotated Term	Reference
Ppa1^em1Cya/Ppa1⁺ involves: C57BL/6JCya	abnormal adipose tissue distribution	J:361168
	abnormal fat cell mitochondrial morphology	J:361168
	abnormal white adipose tissue morphology	J:361168
	abnormal white fat cell size	J:361168
	decreased carbon dioxide production	J:361168
	decreased circulating adiponectin level	J:361168
	decreased energy expenditure	J:361168
	decreased epididymal fat pad weight	J:361168
	decreased fat cell mitochondrial DNA content	J:361168
	decreased lean body mass	J:361168
	decreased mitochondrial number	J:361168
	decreased mitochondrial size	J:361168
	decreased oxygen consumption	J:361168
	decreased respiratory quotient	J:361168
	decreased subcutaneous adipose tissue amount	J:361168
	decreased total body fat amount	J:361168
	decreased white fat cell size	J:361168
	impaired glucose tolerance	J:361168
	increased body fat mass	J:361168
	increased circulating free fatty acids level	J:361168
	increased circulating glucose level	J:361168
	increased circulating insulin level	J:361168
	increased circulating triglyceride level	J:361168
	increased fatty acids level	J:361168
	increased liver free fatty acids level	J:361168
	increased liver triglyceride level	J:361168
	increased liver weight	J:361168
	increased muscle free fatty acids level	J:361168
	increased skeletal muscle triglyceride level	J:361168
	increased susceptibility to diet-induced hepatic steatosis	J:361168
	increased susceptibility to diet-induced obesity	J:361168
	increased triglyceride level	J:361168
	insulin resistance	J:361168
Ppa1^em1Cya/Ppa1^em1Cya involves: C57BL/6JCya	lethality, complete penetrance	J:361168

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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