Ppa1^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ppa1^em1Cya
• Name: pyrophosphatase (inorganic) 1; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:8275795
• Synonyms: Ppa1^em1
• Gene: Ppa1 Location: Chr10:61484400-61509944 bp, + strand Genetic Position: Chr10, 32.25 cM, cytoband B4
• Alliance: Ppa1^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6JCya

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/cas9-mediated recombination targeting exons 3-8 created a deletion allele. (J:326541)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppa1 Mutation: 30 strains or lines available

References

• Original: J:361168 Yin Y, et al., PPA1 Regulates Systemic Insulin Sensitivity by Maintaining Adipocyte Mitochondria Function as a Novel PPARgamma Target Gene. Diabetes. 2021 Jun;70(6):1278-1291
• All: 2 reference(s)