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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Igh-V
immunoglobulin heavy chain variable region
MGI:96477
9 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Igh-Vtm1(Igh-Vx24)Hmb/Igh-Vtm1(Igh-Vx24)Hmb
involves: 129/Sv * C57BL/6 		increased apoptosis J:54380
increased cell proliferation J:54380
increased lymphoma incidence J:54380
increased T cell derived lymphoma incidence J:54380
Ighmtm1Cgn/Ighm+
Tg(Igh-6/Igh-V281)3Jwt/0
NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V281)3Jwt 		insulitis J:91865
Ighmtm1Cgn/Ighm+
Tg(Igh-6/Igh-V125)2Jwt/0
Tg(Igk-C/Igk-V125)1Jwt/0
NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V125)2Jwt Tg(Igk-C/Igk-V125)1Jwt 		increased circulating glucose level J:91865
increased susceptibility to autoimmune diabetes J:91865
insulitis J:91865
Ighmtm1Cgn/Ighmtm1Cgn
Tg(Igh-6/Igh-V125)2Jwt/0
Tg(Igk-C/Igk-V125)1Jwt/0
NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V125)2Jwt Tg(Igk-C/Igk-V125)1Jwt 		insulitis J:91865
Ighmtm1Cgn/Ighmtm1Cgn
Tg(Igh-6/Igh-V281)3Jwt/0
NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V281)3Jwt 		insulitis J:91865
Tg(Igh-6/Igh-V125)2Jwt/0
Tg(Igk-C/Igk-V125)1Jwt/0
NOD.B6-Tg(Igh-6/Igh-V125)2Jwt Tg(Igk-C/Igk-V125)1Jwt 		abnormal B cell number J:91865
increased circulating glucose level J:91865
increased susceptibility to autoimmune diabetes J:91865
insulitis J:91865
Tg(Igh-6/Igh-V281)3Jwt/0
NOD.B6-Tg(Igh-6/Igh-V281)3Jwt 		decreased susceptibility to autoimmune diabetes J:91865
insulitis J:91865
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory