Igh-V Complex/Cluster/Region Detail

Summary

• Symbol
  Igh-V
• Name
  immunoglobulin heavy chain variable region
• Synonyms
  B1H12, B4H2, Gal13, M86

• Feature Type
  complex/cluster/region
• IDs
  MGI:96477
  NCBI Gene: 16049
• Regulated by
  Rr695579, Rr695580, Rr695581 ... (4 regulatory regions)

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 12, Syntenic
• Mapping Data
  19 experiments

Strain
Comparison

• PCR
  8
• RFLP
  3

Human Diseases

• Mutations/Alleles
  2 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotypes from 1 allele in 1 genetic background
  9 phenotypes from multigenic genotypes
  20 phenotype references
  

• All Mutations and Alleles
  6
• Targeted
  4
• Transgenic
  2
• Find Mice (IMSR)
  5 strains or lines available

Mice homozygous for disruptions in this gene have very poor T independent immune responses. T dependent responses are better but still poor. They are highly susceptible to infection by encapsulated bacteria.

Expression

• Other Mouse Links
  GEO

Sequences &
Gene Models

• All Sequences
  6

• NCBI Gene
  16049

Representative Sequences			Length	Strain/Species
genomic	M31639	GenBank | ENA | DDBJ | MGI Sequence Detail	686	BALB/c
transcript	AJ277813	GenBank | ENA | DDBJ | MGI Sequence Detail	408	Not Specified

Molecular
Reagents

• All nucleic 38

  Genomic 24

  cDNA 11

  Primer pair 3

Other
Accession IDs

MGD-MRK-11275

References

• Summaries
  All 88

  Diseases 1

  Phenotypes 20
• Earliest
  J:5725 Berek C, et al., Genetics of the idotype of BALB/c myeloma S117: multiple chromosomal loci for Vh genes encoding specificity for group A streptococcal carbohydrate. J Exp Med. 1976 Nov 2;144(5):1164-74
• Latest
  J:362325 Alleva DG, et al., An antigen-specific immunotherapeutic, AKS-107, deletes insulin-specific B cells and prevents murine autoimmune diabetes. Front Immunol. 2024;15:1367514

Igh-V expression regulated by:

Feature	Feature Type	Location	Reference
Rr695579, regulatory region 695579	enhancer	Chr12:114146020-114146820	J:372216
Rr695580, regulatory region 695580	enhancer	Chr12:114572720-114573520	J:372216
Rr695581, regulatory region 695581	enhancer	Chr12:114987020-114987920	J:372216
Rr695582, regulatory region 695582	enhancer	Chr12:115221120-115222020	J:372216