Cyp27a1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
MGI:88594

38 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cyp27a1^{tm1.1(KOMP)Vlcg}/Cyp27a1^{tm1.1(KOMP)Vlcg} C57BL/6N-Cyp27a1^{tm1.1(KOMP)Vlcg}/Ucd	abnormal heart morphology	J:211773
	decreased circulating cholesterol level	J:211773
	decreased circulating HDL cholesterol level	J:211773
	decreased circulating serum albumin level	J:211773
	decreased circulating triglyceride level	J:211773
	decreased heart rate	J:211773
	decreased mean platelet volume	J:211773
	enlarged heart	J:211773
	improved glucose tolerance	J:211773
	increased circulating alkaline phosphatase level	J:211773
	increased lean body mass	J:211773
	increased liver weight	J:211773
	prolonged RR interval	J:211773
	shortened QRS complex duration	J:211773
Cyp27a1^tm1Elt/Cyp27a1^tm1Elt B6.129-Cyp27a1^tm1Elt/J	abnormal vitamin D level	J:223194
	decreased circulating phosphate level	J:223194
	enlarged liver	J:223194
Cyp27a1^tm1Elt/Cyp27a1^tm1Elt involves: 129/Sv * C57BL/6J	abnormal bile composition	J:48127, J:115373
	abnormal bile salt homeostasis	J:115373
	abnormal circulating cholesterol level	J:48127
	abnormal feces composition	J:115373
	abnormal vitamin D level	J:48127
	decreased bile salt level	J:115373
	decreased brain weight	J:115373
	decreased cholesterol level	J:115373
	decreased intestinal cholesterol absorption	J:115373
	decreased kidney weight	J:115373
	enlarged adrenal glands	J:115373
	enlarged adrenocortical cells	J:115373
	enlarged liver	J:115373
	normal homeostasis/metabolism phenotype	J:115373
	increased adrenal gland weight	J:115373
	increased cholesterol level	J:48127, J:115373
	increased circulating cholesterol level	J:115373
	increased circulating triglyceride level	J:115373
	increased circulating VLDL cholesterol level	J:115373
	increased circulating VLDL triglyceride level	J:115373
	increased fatty acids level	J:115373
	increased liver triglyceride level	J:115373
	increased liver weight	J:115373
	increased sterol level	J:115373

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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