54 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cacna1dtm1Hgn/Cacna1dtm1Hgn Egr2tm2(cre)Pch/Egr2+ involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ	abnormal auditory brainstem response waveform shape	J:185977
	abnormal distortion product otoacoustic emission	J:185977
	abnormal pons morphology	J:185977
	decreased neuron number	J:185977
	increased or absent distortion product otoacoustic emission threshold	J:185977
Cacna1dtm1Hssh/Cacna1d+ involves: 129S4/SvJae * C57BL/6J	increased or absent threshold for auditory brainstem response	J:118306
Cacna1dtm1Hssh/Cacna1dtm1Hssh involves: 129S4/SvJae * C57BL/6J	abnormal calcium ion homeostasis	J:72316
	abnormal cochlear outer hair cell physiology	J:118306
	abnormal pancreatic beta cell differentiation	J:72316
	abnormal pancreatic beta cell physiology	J:72316
	abnormal pancreatic islet morphology	J:72316
	absent distortion product otoacoustic emissions	J:118306
	absent outer hair cell stereocilia	J:118306
	absent pinna reflex	J:72316, J:118306
	cochlear ganglion degeneration	J:118306
	cochlear outer hair cell degeneration	J:118306
	deafness	J:72316, J:118306
	decreased body weight	J:72316
	decreased circulating insulin level	J:72316
	decreased insulin secretion	J:72316
	decreased pancreatic beta cell mass	J:72316
	decreased pancreatic beta cell number	J:72316
	decreased pancreatic beta cell proliferation	J:72316
	decreased pancreatic islet number	J:72316
	impaired glucose tolerance	J:72316
	increased insulin sensitivity	J:72316
	increased or absent threshold for auditory brainstem response	J:72316, J:118306
	increased pancreatic alpha cell number	J:72316
Cacna1dtm1Jst/Cacna1dtm1Jst B6.129S7-Cacna1dtm1Jst	abnormal cochlear IHC afferent innervation pattern	J:88205, J:108908, J:113161
	abnormal cochlear IHC efferent innervation pattern	J:88205, J:108908, J:113161
	abnormal cochlear inner hair cell physiology	J:88205, J:113161
	abnormal cochlear nerve morphology	J:85915
	abnormal inner hair cell synaptic ribbon morphology	J:113161
	absent active-zone-anchored inner hair cell synaptic ribbon	J:108908
	absent pinna reflex	J:85915, J:108908
	normal behavior/neurological phenotype	J:85915
	cochlear ganglion degeneration	J:108908, J:113161
	cochlear hair cell degeneration	J:108908
	cochlear inner hair cell degeneration	J:85915, J:108908, J:113161
	cochlear outer hair cell degeneration	J:108908
	deafness	J:108908
	decreased body weight	J:85915
	normal homeostasis/metabolism phenotype	J:85915
	normal nervous system phenotype	J:85915
	sensorineural hearing loss	J:108908
Cacna1dtm1Jst/Cacna1dtm1Jst involves: 129S7/SvEvBrd * C57BL/6J	abnormal action potential	J:230439
	abnormal calcium ion homeostasis	J:63515
	abnormal cochlear inner hair cell physiology	J:63515, J:117764
	abnormal cochlear outer hair cell physiology	J:117764
	abnormal distortion product otoacoustic emission	J:117764
	abnormal heart rate	J:230439
	abnormal myocardial fiber physiology	J:230439
	abnormal sinoatrial node conduction	J:63515, J:230439
	abnormal sinus arrhythmia	J:63515
	absent pinna reflex	J:63515
	atrial fibrillation	J:230439
	atrioventricular block	J:63515, J:230439
	cochlear ganglion degeneration	J:63515
	cochlear inner hair cell degeneration	J:63515
	cochlear outer hair cell degeneration	J:63515, J:117764
	deafness	J:63515, J:117764
	decreased heart rate	J:63515
	heart block	J:230439
	normal homeostasis/metabolism phenotype	J:63515
	increased heart rate	J:230439
	increased heart rate variability	J:230439
	increased or absent threshold for auditory brainstem response	J:63515, J:117764
	normal mortality/aging	J:63515
	prolonged PR interval	J:63515, J:230439
	prolonged RR interval	J:63515
	sensorineural hearing loss	J:63515
	sinus bradycardia	J:230439