Dok6 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dok6
docking protein 6
MGI:3639495

27 phenotypes from 3 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dok6^em1(IMPC)J/Dok6^em1(IMPC)J C57BL/6NJ-Dok6^em1(IMPC)J/Mmjax	absent vibrissae	J:211773
Dok6^tm1.1Pnxi/Dok6^tm1.1Pnxi Cnp^tm1(cre)Kan/Cnp⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	normal behavior/neurological phenotype	J:345844
	normal nervous system phenotype	J:345844
Dok6^tm1.1Pnxi/Dok6^tm1.1Pnxi Tg(Avil-cre)1Phep/0 involves: 129S4/SvJaeSor * C57BL/6	abnormal action potential	J:345844
	abnormal axonal transport	J:345844
	abnormal myelin sheath morphology	J:345844
	abnormal myelination	J:345844
	axon degeneration	J:345844
	decreased grip strength	J:345844
	decreased myelin sheath amount	J:345844
	decreased nerve conduction velocity	J:345844
	impaired balance	J:345844
	impaired coordination	J:345844
	impaired exercise endurance	J:345844
	increased myelin sheath thickness	J:345844
	increased thermal nociceptive threshold	J:345844
Dok6^tm1.1Pnxi/Dok6^tm1.1Pnxi Tg(Scn10a-cre)1Rkun/0 involves: C57BL/6 * DBA/2	abnormal myelin sheath morphology	J:345844
Dok6^tm1.2Pnxi/Dok6⁺ involves: C57BL/6 * FVB/N	abnormal gait	J:345844
Dok6^tm1.2Pnxi/Dok6^tm1.2Pnxi involves: C57BL/6 * FVB/N	abnormal action potential	J:345844
	abnormal autopod morphology	J:345844
	abnormal axon radial sorting	J:345844
	abnormal gait	J:345844
	abnormal hindlimb morphology	J:345844
	abnormal limb posture	J:345844
	abnormal myelin sheath morphology	J:345844
	abnormal myelination	J:345844
	abnormal posture	J:345844
	abnormal proprioceptive neuron morphology	J:345844
	axon degeneration	J:345844
	decreased grip strength	J:345844
	decreased myelin sheath amount	J:345844
	decreased nerve conduction velocity	J:345844
	decreased sensory neuron number	J:345844
	dysmyelination	J:345844
	hypermyelination	J:345844
	impaired balance	J:345844
	impaired coordination	J:345844
	impaired exercise endurance	J:345844
	increased thermal nociceptive threshold	J:345844
	tomacula	J:345844

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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