Aim2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Aim2
absent in melanoma 2
MGI:2686159

24 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Aim2^{em1(IMPC)Ccpcz}/Aim2^{em1(IMPC)Ccpcz} C57BL/6N-Aim2^{em1(IMPC)Ccpcz}/Ccpcz	abnormal gallbladder morphology	J:211773
	abnormal spleen morphology	J:211773
	abnormal thymus morphology	J:211773
	enlarged gallbladder	J:211773
	enlarged spleen	J:211773
	enlarged thymus	J:211773
	increased circulating serum albumin level	J:211773
	increased circulating total protein level	J:211773
Aim2^{Gt(CSG445)Byg}/Aim2^{Gt(CSG445)Byg} B6.129P2-Aim2^{Gt(CSG445)Byg}/J	abnormal interferon secretion	J:234263
	decreased interleukin-1 beta secretion	J:234263
	decreased macrophage apoptosis	J:234263
Aim2^{Gt(CSG445)Byg}/Aim2^{Gt(CSG445)Byg} involves: 129P2/OlaHsd	normal immune system phenotype	J:173245
Aim2^{Gt(CSG445)Byg}/Aim2^{Gt(CSG445)Byg} involves: 129P2/OlaHsd * C57BL/6	abnormal macrophage physiology	J:158969
	decreased circulating interleukin-18 level	J:158969
	decreased interleukin-1 beta secretion	J:158969
	decreased interleukin-18 secretion	J:158969
	decreased NK cell number	J:158969
	increased interferon-beta secretion	J:158969
	increased susceptibility to bacterial infection	J:158969
	increased susceptibility to Herpesvirales infection	J:158969
	increased susceptibility to Poxviridae infection	J:158969
Aim2^tm1.1Vmd/Aim2^tm1.1Vmd C57BL/6-Aim2^tm1.1Vmd	abnormal cytokine secretion	J:160545
	abnormal macrophage physiology	J:160545
	decreased interleukin-1 beta secretion	J:160545
	decreased interleukin-18 secretion	J:160545
	increased interferon-beta secretion	J:160545
	increased susceptibility to bacterial infection	J:160545
	increased tumor necrosis factor secretion	J:160545
Aim2^tm1Ktak/Aim2^tm1Ktak involves: 129S4/SvJae * C57BL/6	decreased circulating interleukin-18 level	J:188013
	decreased interferon-gamma secretion	J:188013
	decreased interleukin-1 beta secretion	J:188013
	decreased interleukin-18 secretion	J:188013
	increased susceptibility to bacterial infection	J:188013
	increased susceptibility to bacterial infection induced morbidity/mortality	J:188013

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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