Aim2^tm1Ktak
Targeted Allele Detail

Summary

• Symbol: Aim2^tm1Ktak
• Name: absent in melanoma 2; targeted mutation 1, Kiyoshi Takeda
• MGI ID: MGI:5441076
• Gene: Aim2 Location: Chr1:173178445-173293606 bp, + strand Genetic Position: Chr1, 80.33 cM
• Alliance: Aim2^tm1Ktak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188013
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced exon 3. Northern blot analysis confirmed the absence of transcript expression in bone marrow cells cultured in the presence of GM-CSF and stimulated with IFNgamma. (J:188013)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aim2 Mutation: 32 strains or lines available

References

• Original: J:188013 Saiga H, et al., Critical role of AIM2 in Mycobacterium tuberculosis infection. Int Immunol. 2012 Oct;24(10):637-44
• All: 1 reference(s)