Thrap3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Thrap3
thyroid hormone receptor associated protein 3
MGI:2442637

25 phenotypes from 1 allele in 1 genetic background

Allelic Composition Genetic Background	Annotated Term	Reference
Thrap3^{tm1c(KOMP)Wtsi}/Thrap3^{tm1c(KOMP)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: C57BL/6 * C57BL/6J * C57BL/6N * DBA	abnormal autophagosome formation	J:339439
	abnormal hepatocyte physiology	J:339439
	abnormal liver physiology	J:339439
	abnormal mitochondrial ATP synthesis coupled electron transport	J:339439
	abnormal mitochondrial crista morphology	J:339439
	abnormal mitophagy	J:339439
	abnormal respiratory electron transport chain	J:339439
	decreased body weight	J:339439
	decreased circulating alanine transaminase level	J:339439
	decreased circulating aspartate transaminase level	J:339439
	decreased circulating cholesterol level	J:339439
	decreased circulating free fatty acids level	J:339439
	decreased circulating glucose level	J:339439
	decreased circulating insulin level	J:339439
	decreased circulating triglyceride level	J:339439
	decreased liver cholesterol level	J:339439
	decreased liver triglyceride level	J:339439
	decreased susceptibility to diet-induced hepatic steatosis	J:339439
	enhanced autophagy	J:339439
	improved glucose tolerance	J:339439
	increased energy expenditure	J:339439
	increased hepatocyte mitochondrial DNA content	J:339439
	increased insulin sensitivity	J:339439
	increased mitochondrial size	J:339439
	increased oxygen consumption	J:339439

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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