Rapgef3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rapgef3
Rap guanine nucleotide exchange factor (GEF) 3
MGI:2441741

33 phenotypes from 6 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rapgef3^tm1.1Chen/Rapgef3^tm1.1Chen B6.129(Cg)-Rapgef3^tm1.1Chen	abnormal adipose tissue development	J:207599
	abnormal glucose homeostasis	J:207599
	decreased body weight	J:207599
	decreased circulating glucose level	J:207599
	decreased circulating insulin level	J:207599
	decreased circulating leptin level	J:207599
	decreased epididymal fat pad weight	J:207599
	decreased food intake	J:207599
	decreased total body fat amount	J:207599
	decreased white fat cell size	J:207599
	improved glucose tolerance	J:207599
	increased insulin sensitivity	J:207599
	slow postnatal weight gain	J:207599
Rapgef3^tm1.1Geno/Rapgef3^tm1.1Geno Tg(Camk2a-cre)2Szi/0 involves: 129S2/SvPas * C57BL/6J * CBA	normal nervous system phenotype	J:182701
Rapgef3^tm1.2Chen/Rapgef3^tm1.2Chen involves: 129 * Black Swiss * C57BL/6 * SJL	normal cardiovascular system phenotype	J:210426
Rapgef3^tm1Fsel/Rapgef3^tm1Fsel involves: C57BL/6JBomTac	normal hematopoietic system phenotype	J:210778
Rapgef3^tm1Skc/Rapgef3^tm1Skc Not Specified	abnormal pancreatic beta cell physiology	J:201171
	decreased blood urea nitrogen level	J:201171
	decreased circulating cholesterol level	J:201171
	decreased circulating HDL cholesterol level	J:201171
	decreased circulating insulin level	J:201171
	decreased insulin secretion	J:201171
	enlarged pancreatic islets	J:201171
	hyperglycemia	J:201171
	impaired glucose tolerance	J:201171
	increased body weight	J:201171
	increased circulating triglyceride level	J:201171
	increased pancreatic alpha cell number	J:201171
	increased respiratory quotient	J:201171
	increased susceptibility to diet-induced obesity	J:201171
	insulin resistance	J:201171
	insulitis	J:201171
	pancreatic islet hyperplasia	J:201171
Rapgef3^tm1Utak/Rapgef3^tm1Utak involves: C57BL/6 * CBA	decreased neuron apoptosis	J:170436

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23