Rapgef3^tm1Skc
Targeted Allele Detail

Summary

• Symbol: Rapgef3^tm1Skc
• Name: Rap guanine nucleotide exchange factor (GEF) 3; targeted mutation 1, Sookja K Chung
• MGI ID: MGI:5532318
• Gene: Rapgef3 Location: Chr15:97642651-97665853 bp, - strand Genetic Position: Chr15, 53.74 cM
• Alliance: Rapgef3^tm1Skc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201171
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 8 through 21. Western blot analysis confirmed the absence of protein expression in the heart, kidney, pancreas and brain. (J:201171)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rapgef3 Mutation: 45 strains or lines available

References

• Original: J:201171 Kai AK, et al., Exchange protein activated by cAMP 1 (Epac1)-deficient mice develop beta-cell dysfunction and metabolic syndrome. FASEB J. 2013 Oct;27(10):4122-4135
• All: 4 reference(s)