Rapgef3^tm1Fsel
Targeted Allele Detail

Summary

• Symbol: Rapgef3^tm1Fsel
• Name: Rap guanine nucleotide exchange factor (GEF) 3; targeted mutation 1, Frode Selheim
• MGI ID: MGI:5574090
• Gene: Rapgef3 Location: Chr15:97642651-97665853 bp, - strand Genetic Position: Chr15, 53.74 cM
• Alliance: Rapgef3^tm1Fsel page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210778
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 7 to 10, which encodes the cAMP-binding domain, were excised. (J:210778)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rapgef3 Mutation: 45 strains or lines available

References

• Original: J:210778 Herfindal L, et al., Off-target effect of the Epac agonist 8-pCPT-2'-O-Me-cAMP on P2Y12 receptors in blood platelets. Biochem Biophys Res Commun. 2013 Aug 9;437(4):603-8
• All: 1 reference(s)