Ell2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ell2
elongation factor for RNA polymerase II 2
MGI:2183438

21 phenotypes from 4 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cd19^tm1(cre)Cgn/Cd19⁺ Ell2^tm1.1Cmil/Ell2^tm1.1Cmil involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	abnormal endoplasmic reticulum morphology	J:234692
	decreased IgA level	J:234692
	decreased IgG1 level	J:234692
	decreased IgM level	J:234692
	decreased immunoglobulin level	J:234692
	decreased mature B cell number	J:234692
	decreased plasma cell number	J:234692
	decreased transitional stage T1 B cell number	J:234692
	decreased transitional stage T2 B cell number	J:234692
	decreased transitional stage T3 B cell number	J:234692
	impaired humoral immune response	J:234692
	increased follicular B cell number	J:234692
	increased immature B cell number	J:234692
	increased pre-B cell number	J:234692
	increased pro-B cell number	J:234692
Cd19^tm1(cre)Cgn/Cd19⁺ Ell2^tm2.1Cmil/Ell2^tm2.1Cmil involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	decreased IgA level	J:234692
	decreased IgG1 level	J:234692
	decreased IgM level	J:234692
	decreased immunoglobulin level	J:234692
	decreased mature B cell number	J:234692
Ell2^{tm1a(EUCOMM)Wtsi}/Ell2^{tm1a(EUCOMM)Wtsi} C57BL/6N-Ell2^{tm1a(EUCOMM)Wtsi}/Wtsi	abnormal lens morphology	J:211773
	cataract	J:211773
	decreased circulating serum albumin level	J:211773
	increased circulating alkaline phosphatase level	J:211773
	increased grip strength	J:211773
Ell2^{tm1b(EUCOMM)Wtsi}/Ell2^{tm1b(EUCOMM)Wtsi} C57BL/6N-Ell2^{tm1b(EUCOMM)Wtsi}/Wtsi	abnormal lens morphology	J:211773
	abnormal retina morphology	J:211773
	cataract	J:211773
	increased circulating alkaline phosphatase level	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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