Pld4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pld4
phospholipase D family member 4
MGI:2144765

39 phenotypes from 5 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lyz2^tm1(cre)Ifo/0 Pld4^tm1.1Nemz/Pld4^tm1.1Nemz involves: 129 * 129P2/OlaHsd * C57BL/6J	normal hematopoietic system phenotype	J:281205
Pld4^em1(IMPC)Mbp/Pld4^em1(IMPC)Mbp C57BL/6N-Pld4^em1(IMPC)Mbp/MbpMmucd	abnormal spleen morphology	J:211773
	cornea opacity	J:211773
	decreased circulating calcium level	J:211773
	enlarged spleen	J:211773
	eye hemorrhage	J:211773
	increased leukocyte cell number	J:211773
	increased monocyte cell number	J:211773
	increased spleen weight	J:211773
Pld4^mpc96H/Pld4^mpc96H involves: BALB/c * C3H/HeH * C57BL/6J	decreased body size	J:234901
Pld4^thss/Pld4^thss BALB/cJ-Pld4^thss/GrsrJ	abnormal alpha-beta T cell morphology	J:278304
	abnormal immunoglobulin level	J:278304
	decreased body size	J:171492
	decreased body weight	J:278304
	enlarged lymph nodes	J:278304
	enlarged spleen	J:278304
	increased anti-nuclear antigen antibody level	J:278304
	increased IgA level	J:278304
	increased IgE level	J:278304
	increased IgG2b level	J:278304
	increased IgG3 level	J:278304
	increased IgG level	J:278304
	increased IgM level	J:278304
	increased macrophage cell number	J:278304
	increased marginal zone B cell number	J:278304
	increased plasma cell number	J:278304
	increased plasmacytoid dendritic cell number	J:278304
	increased spleen germinal center number	J:278304
	lymph node hyperplasia	J:278304
	normal mortality/aging	J:278304
	renal glomerular immunoglobulin deposits	J:278304
	sparse hair	J:171492
	spleen hyperplasia	J:278304
Pld4^tm1.1Nemz/Pld4^tm1.1Nemz Tg(Itgax-cre)1-1Reiz/0 involves: 129 * C57BL/6 * C57BL/6J * CBA	abnormal peritoneal macrophage morphology	J:281205
Pld4^tm1.2Nemz/Pld4^tm1.2Nemz B6.129(Cg)-Pld4^tm1.1Nemz	abnormal leukocyte cell number	J:281205
	abnormal peritoneal macrophage morphology	J:281205
	decreased B-1 B cell number	J:281205
	decreased NK T cell number	J:281205
	enlarged spleen	J:281205
	normal immune system phenotype	J:281205
	increased circulating CXCL10 level	J:281205
	increased circulating interferon-gamma level	J:281205
	increased marginal zone B cell number	J:281205
	increased monocyte cell number	J:281205
	normal mortality/aging	J:281205
	thrombocytopenia	J:281205

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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