Pcsk9 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pcsk9
proprotein convertase subtilisin/kexin type 9
MGI:2140260

10 phenotypes from 5 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pcsk9^m1Bms/Pcsk9⁺ B6.Cg-Pcsk9^m1Bms	decreased circulating LDL cholesterol level	J:200728
Pcsk9^m1Bms/Pcsk9^m1Bms B6.Cg-Pcsk9^m1Bms	decreased circulating LDL cholesterol level	J:200728
Pcsk9^m1Bms/Pcsk9^m1Bms B6.Cg-Pcsk9^m1Bms	increased bile salt level	J:200728
Pcsk9^tm1.1Prat/Pcsk9^tm1.1Prat Speer6-ps1^{Tg(Alb-cre)21Mgn}/? involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA	decreased circulating cholesterol level	J:169834
	decreased circulating HDL cholesterol level	J:169834
	decreased circulating LDL cholesterol level	J:169834
Pcsk9^tm1.2Prat/Pcsk9^tm1.2Prat involves: 129S1/Sv * 129X1/SvJ	abnormal cholesterol homeostasis	J:169834
	abnormal liver regeneration	J:169834
	decreased circulating cholesterol level	J:169834
	decreased circulating HDL cholesterol level	J:169834
	decreased circulating LDL cholesterol level	J:169834
	impaired liver regeneration	J:169834
Pcsk9^tm1Jdh/Pcsk9^tm1Jdh involves: 129S6/SvEvTac	decreased circulating cholesterol level	J:97836
	decreased circulating HDL cholesterol level	J:97836
	decreased circulating LDL cholesterol level	J:97836
Pcsk9^{tm2b(EUCOMM)Hmgu}/Pcsk9^{tm2b(EUCOMM)Hmgu} C57BL/6N-Pcsk9^{tm2b(EUCOMM)Hmgu}/Ieg	decreased circulating cholesterol level	J:211773
	decreased circulating HDL cholesterol level	J:211773
	increased circulating alkaline phosphatase level	J:211773
	increased circulating amylase level	J:211773
	increased circulating lipase level	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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