Mettl3 Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mettl3
methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit
MGI:1927165

17 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Mettl3^em1Chhe/Mettl3^em1Chhe Mettl14^em1Chhe/Mettl14^em1Chhe Stra8^{em1(GFP/cre)Smoc}/Stra8⁺ involves: C57BL/6J	abnormal elongated spermatid morphology	J:250428
	abnormal epigenetic regulation of gene expression	J:250428
	abnormal seminiferous tubule morphology	J:250428
	abnormal sperm head morphology	J:250428
	arrest of spermiogenesis	J:250428
	asthenozoospermia	J:250428
	decreased elongated spermatid number	J:250428
	decreased sperm progressive motility	J:250428
	decreased testis weight	J:250428
	impaired translation	J:250428
	oligozoospermia	J:250428
	small testis	J:250428
	teratozoospermia	J:250428
Mettl3^em1Chhe/Mettl3^em1Chhe Mettl14^em1Chhe/Mettl14^em1Chhe Tg(Ddx4-cre)1Dcas/0 involves: C57BL/6J * FVB	absent spermatogonia	J:250428
	decreased male germ cell number	J:250428
Mettl3^tm1.1Jhha/Mettl3^tm1.1Jhha Tg(Prm-cre)58Og/0 involves: 129S4/SvJae * 129S4/SvJaeSor * BALB/c * C57BL/6	normal reproductive system phenotype	J:299108

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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