About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mettl3
methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit
MGI:1927165
39 phenotypes from 5 alleles in 10 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Mettl3em1(IMPC)Tcp/Mettl3em1(IMPC)Tcp
C57BL/6N-Mettl3em1(IMPC)Tcp/Tcp 		preweaning lethality, complete penetrance J:211773
Mettl3em1(IMPC)Tcp/Mettl3em1(IMPC)Tcp
C57BL/6NCrl-Mettl3em1(IMPC)Tcp/TcpMmucd 		embryonic lethality prior to organogenesis J:211773
embryonic lethality prior to tooth bud stage J:211773
Mettl3em1Chhe/Mettl3em1Chhe
Stra8em1(GFP/cre)Smoc/Stra8+
involves: C57BL/6J 		abnormal epigenetic regulation of gene expression J:250428
normal reproductive system phenotype J:250428
Mettl3em1Chhe/Mettl3em1Chhe
Tg(Ddx4-cre)1Dcas/0
involves: C57BL/6J * FVB 		abnormal epigenetic regulation of gene expression J:250428
abnormal male germ cell morphology J:250428
abnormal seminiferous tubule epithelium morphology J:250428
abnormal spermatogonia proliferation J:250428
abnormal translation J:250428
absent spermatogonia J:250428
decreased male germ cell number J:250428
decreased spermatogonia number J:250428
male infertility J:250428
small testis J:250428
Mettl3em1Sxiao/Mettl3+
involves: C57BL/6 		abnormal cellular respiration J:385020
abnormal DNA-templated transcription J:385020
decreased locomotor activity J:385020
decreased mitochondrial DNA content J:385020
impaired limb coordination J:385020
impaired olfaction J:385020
increased freezing behavior J:385020
loss of dopaminergic neurons J:385020
oxidative stress J:385020
short stride length J:385020
weakness J:385020
Mettl3em1Sxiao/Mettl3em1Sxiao
involves: C57BL/6 		prenatal lethality, complete penetrance J:385020
Mettl3tm1.1Jhha/Mettl3tm1.1Jhha
Tg(Ddx4-cre)1Dcas/0
involves: 129S4/SvJaeSor * BALB/c * C57BL/6 * FVB 		abnormal ovary morphology J:299108
female infertility J:299108
male infertility J:299108
small testis J:299108
testis degeneration J:299108
Mettl3tm1.1Jhha/Mettl3tm1.1Jhha
Tg(Prm-cre)58Og/0
involves: 129S4/SvJae * 129S4/SvJaeSor * BALB/c * C57BL/6 		normal reproductive system phenotype J:299108
Mettl3tm1.1Jhha/Mettl3tm1.1Jhha
Tg(Stra8-icre)1Reb/0
involves: 129S4/SvJaeSor * BALB/c * C57BL/6 * FVB/NJ 		oligozoospermia J:299108
reduced male fertility J:299108
seminiferous tubule degeneration J:299108
small testis J:299108
Mettl3tm1.1Jhha/Mettl3tm1.1Jhha
Tg(Zp3-cre)93Knw/0
involves: 129S4/SvJaeSor * BALB/c * C57BL/6 * C57BL/6J 		abnormal female meiosis J:299108
abnormal oocyte morphology J:299108
decreased oocyte number J:299108
normal endocrine/exocrine gland phenotype J:299108
female infertility J:299108
Mettl3tm1Jhha/Mettl3tm1Jhha
involves: 129S4/SvJae * C57BL/6 		abnormal egg cylinder morphology J:219587
abnormal embryo development J:219587
embryonic lethality between implantation and placentation, complete penetrance J:219587
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
06/09/2026
MGI 6.24 		The Jackson Laboratory