Mettl3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mettl3
methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit
MGI:1927165

26 phenotypes from 4 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mettl3^em1(IMPC)Tcp/Mettl3^em1(IMPC)Tcp C57BL/6N-Mettl3^em1(IMPC)Tcp/Tcp	preweaning lethality, complete penetrance	J:211773
Mettl3^em1(IMPC)Tcp/Mettl3^em1(IMPC)Tcp C57BL/6NCrl-Mettl3^em1(IMPC)Tcp/TcpMmucd	embryonic lethality prior to organogenesis	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
Mettl3^em1Chhe/Mettl3^em1Chhe Stra8^{em1(GFP/cre)Smoc}/Stra8⁺ involves: C57BL/6J	abnormal epigenetic regulation of gene expression	J:250428
	normal reproductive system phenotype	J:250428
Mettl3^em1Chhe/Mettl3^em1Chhe Tg(Ddx4-cre)1Dcas/0 involves: C57BL/6J * FVB	abnormal epigenetic regulation of gene expression	J:250428
	abnormal male germ cell morphology	J:250428
	abnormal male germ cell physiology	J:250428
	abnormal seminiferous tubule epithelium morphology	J:250428
	abnormal spermatogonia morphology	J:250428
	abnormal translation	J:250428
	decreased male germ cell number	J:250428
	male infertility	J:250428
	small testis	J:250428
Mettl3^tm1.1Jhha/Mettl3^tm1.1Jhha Tg(Ddx4-cre)1Dcas/0 involves: 129S4/SvJaeSor * BALB/c * C57BL/6 * FVB	abnormal ovary morphology	J:299108
	female infertility	J:299108
	male infertility	J:299108
	small testis	J:299108
	testis degeneration	J:299108
Mettl3^tm1.1Jhha/Mettl3^tm1.1Jhha Tg(Prm-cre)58Og/0 involves: 129S4/SvJae * 129S4/SvJaeSor * BALB/c * C57BL/6	normal reproductive system phenotype	J:299108
Mettl3^tm1.1Jhha/Mettl3^tm1.1Jhha Tg(Stra8-icre)1Reb/0 involves: 129S4/SvJaeSor * BALB/c * C57BL/6 * FVB/NJ	oligozoospermia	J:299108
	reduced male fertility	J:299108
	seminiferous tubule degeneration	J:299108
	small testis	J:299108
Mettl3^tm1.1Jhha/Mettl3^tm1.1Jhha Tg(Zp3-cre)93Knw/0 involves: 129S4/SvJaeSor * BALB/c * C57BL/6 * C57BL/6J	abnormal female meiosis	J:299108
	abnormal oocyte morphology	J:299108
	decreased oocyte number	J:299108
	normal endocrine/exocrine gland phenotype	J:299108
	female infertility	J:299108
Mettl3^tm1Jhha/Mettl3^tm1Jhha involves: 129S4/SvJae * C57BL/6	abnormal egg cylinder morphology	J:219587
	abnormal embryo development	J:219587
	embryonic lethality between implantation and placentation, complete penetrance	J:219587

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