Clptm1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Clptm1
cleft lip and palate associated transmembrane protein 1
MGI:1927155

28 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Clptm1^em1(IMPC)Tcp/Clptm1⁺ C57BL/6N-Clptm1^em1(IMPC)Tcp/Cmmr	abnormal skin morphology	J:211773
	decreased exploration in new environment	J:211773
	decreased hematocrit	J:211773
	decreased locomotor activity	J:211773
	decreased mean corpuscular hemoglobin	J:211773
	decreased mean corpuscular volume	J:211773
	enlarged lymph nodes	J:211773
	increased anxiety-related response	J:211773
	increased mean corpuscular hemoglobin concentration	J:211773
	increased monocyte cell number	J:211773
Clptm1^em1(IMPC)Tcp/Clptm1^em1(IMPC)Tcp C57BL/6N-Clptm1^em1(IMPC)Tcp/Cmmr	abnormal morula morphology	J:279207
	embryonic lethality before implantation, complete penetrance	J:279207
	embryonic lethality prior to organogenesis	J:211773
	failure of blastocyst to hatch from the zona pellucida	J:279207
	failure of embryo implantation	J:279207
	preweaning lethality, complete penetrance	J:211773
Clptm1^{tm1a(KOMP)Wtsi}/Clptm1⁺ B6J.B6N-Clptm1^{tm1a(KOMP)Wtsi}	abnormal CNS synaptic transmission	J:357551
	abnormal GABA-mediated receptor currents	J:357551
	abnormal hippocampus neuron morphology	J:357551
	impaired contextual conditioning behavior	J:357551
	impaired synaptic plasticity	J:357551
	increased inhibitory postsynaptic current amplitude	J:357551
	increased miniature inhibitory postsynaptic current amplitude	J:357551
	normal nervous system phenotype	J:357551
	reduced long-term potentiation	J:357551
Clptm1^{tm1a(KOMP)Wtsi}/Clptm1^{tm1a(KOMP)Wtsi} B6J.B6N-Clptm1^{tm1a(KOMP)Wtsi}	normal craniofacial phenotype	J:357551
	postnatal lethality, complete penetrance	J:357551
Clptm1^{tm1c(KOMP)Wtsi}/Clptm1^{tm1c(KOMP)Wtsi} involves: C57BL/6J * C57BL/6N * SJL/J	abnormal CNS synaptic transmission	J:357551
	abnormal inhibitory synapse morphology	J:357551
	increased miniature inhibitory postsynaptic current amplitude	J:357551

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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