Appl1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Appl1
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
MGI:1920243

21 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Appl1^{Gt(RRS819)Byg}/Appl1^{Gt(RRS819)Byg} involves: 129P2/OlaHsd * C57BL/6	abnormal brown adipose tissue physiology	J:211794
	abnormal hepatic glucose production	J:211794
	normal behavior/neurological phenotype	J:211794
	normal growth/size/body region phenotype	J:211794
	normal homeostasis/metabolism phenotype	J:211794
	hyperactivity	J:211794
	impaired glucose tolerance	J:211794
	increased circulating insulin level	J:211794
	increased core body temperature	J:211794
	increased fasting circulating glucose level	J:211794
	insulin resistance	J:211794
Appl1^Gt(XM073)Byg/Appl1^Gt(XM073)Byg B6.129P2-Appl1^Gt(XM073)Byg	normal homeostasis/metabolism phenotype	J:164696
	normal immune system phenotype	J:164696
	increased T cell proliferation	J:164696
Appl1^tm1.2Test/Appl1^tm1.2Test involves: 129X1/SvJ	abnormal cell physiology	J:227340
	decreased fibroblast cell migration	J:227340
	normal hematopoietic system phenotype	J:227340
	increased hematocrit	J:227340
	increased T cell proliferation	J:164696
Appl1^tm1.2Test/Appl1^tm1.2Test involves: 129X1/SvJ * C57BL/6	normal cellular phenotype	J:159889
	decreased fibroblast cell migration	J:159889
	normal hematopoietic system phenotype	J:159889
	increased sensitivity to induced cell death	J:159889
Appl1^tm1Ymli/Appl1^tm1Ymli involves: 129S1/Sv * C57BL/6J	decreased vasodilation	J:189487
Appl1^tm1Ymli/Appl1^tm1Ymli involves: 129S1/Sv * C57BL/6J	increased vasoconstriction	J:189487

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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