Appl1 Phenotype Annotations

About Help FAQ

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Appl1
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
MGI:1920243

15 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Appl1^{Gt(RRS819)Byg}/Appl1^{Gt(RRS819)Byg} involves: 129P2/OlaHsd * C57BL/6	abnormal brown adipose tissue physiology	J:211794
	abnormal hepatic glucose production	J:211794
	normal behavior/neurological phenotype	J:211794
	normal growth/size/body region phenotype	J:211794
	normal homeostasis/metabolism phenotype	J:211794
	hyperactivity	J:211794
	impaired glucose tolerance	J:211794
	increased circulating insulin level	J:211794
	increased core body temperature	J:211794
	increased fasting circulating glucose level	J:211794
	insulin resistance	J:211794
Appl1^tm1.2Test/Appl1^tm1.2Test involves: 129X1/SvJ	abnormal cell physiology	J:227340
	decreased fibroblast cell migration	J:227340
	normal hematopoietic system phenotype	J:227340
	increased hematocrit	J:227340
	increased T cell proliferation	J:164696
Appl1^tm1Ymli/Appl1^tm1Ymli involves: 129S1/Sv * C57BL/6J	decreased vasodilation	J:189487
Appl1^tm1Ymli/Appl1^tm1Ymli involves: 129S1/Sv * C57BL/6J	increased vasoconstriction	J:189487

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24