Appl1^tm1Ymli
Targeted Allele Detail

Summary

• Symbol: Appl1^tm1Ymli
• Name: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; targeted mutation 1, Yiming Li
• MGI ID: MGI:5461700
• Gene: Appl1 Location: Chr14:26640943-26692567 bp, - strand Genetic Position: Chr14, 16.09 cM, cytoband B
• Alliance: Appl1^tm1Ymli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189487
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced exons 17 and 18. Western blot confirmed the absence of protein expression in mesenteric arteries. (J:189487)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Appl1 Mutation: 45 strains or lines available

References

• Original: J:189487 Wang Y, et al., APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice. Diabetes. 2011 Nov;60(11):3044-54
• All: 6 reference(s)