All Phenotypes Appl1<tm1Ymli> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Appl1^tm1Ymli
targeted mutation 1, Yiming Li
MGI:5461700

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Appl1^tm1Ymli/Appl1^tm1Ymli	involves: 129S1/Sv * C57BL/6J	MGI:5461706

Allelic Composition	Appl1^tm1Ymli/Appl1^tm1Ymli
Genetic Background	involves: 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Appl1^tm1Ymli mutation (0 available); any Appl1 mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

increased vasoconstriction ( J:189487 )

• mice fed a high fat diet exhibit increased insulin-induced ET-1-dependent vasoconstriction compared with wild-type mice

decreased vasodilation ( J:189487 )

• whether mice are fed standard chow or a high fat diet, arteries exhibit impaired insulin-induced relaxation compared with wild-type mice

muscle

increased vasoconstriction ( J:189487 )

• mice fed a high fat diet exhibit increased insulin-induced ET-1-dependent vasoconstriction compared with wild-type mice

decreased vasodilation ( J:189487 )

• whether mice are fed standard chow or a high fat diet, arteries exhibit impaired insulin-induced relaxation compared with wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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