Insig1 Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Insig1
insulin induced gene 1
MGI:1916289

11 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Insig1^tm1.1Mbjg/Insig1^tm1.1Mbjg Insig2^tm1Mbjg/Insig2⁺ involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N	postnatal lethality	J:101203
Insig1^tm1.1Mbjg/Insig1^tm1.1Mbjg Insig2^tm1Mbjg/Insig2^tm1Mbjg involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N	postnatal lethality	J:101203
Insig1^tm1Mbjg/Insig1^tm1Mbjg Insig2^tm1Mbjg/Insig2^tm1Mbjg Tg(Mx1-cre)29-4Her/0 involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl * SJL	abnormal cholesterol homeostasis	J:101203
	abnormal hepatobiliary system physiology	J:101203
	abnormal lipid homeostasis	J:101203
	abnormal liver morphology	J:101203
	decreased circulating triglyceride level	J:101203
	increased circulating cholesterol level	J:101203
	increased fatty acids level	J:101203
	increased liver cholesterol level	J:101203
	increased liver triglyceride level	J:101203
	pale liver	J:101203

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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