Smarcd3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Smarcd3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
MGI:1914243

45 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Myl1^tm1(cre)Sjb/Myl1⁺ Smarcd3^tm1Jddl/Smarcd3^tm1Jddl involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal muscle physiology	J:256788
	normal growth/size/body region phenotype	J:256788
	impaired glucose tolerance	J:256788
	increased circulating glucose level	J:256788
	insulin resistance	J:256788
Smarcd3^em1(IMPC)J/Smarcd3⁺ C57BL/6NJ-Smarcd3^em1(IMPC)J/J	decreased grip strength	J:211773
Smarcd3^em1(IMPC)J/Smarcd3^em1(IMPC)J C57BL/6NJ-Smarcd3^em1(IMPC)J/J	prenatal lethality	J:211773
	preweaning lethality, complete penetrance	J:211773
Smarcd3^tm1.1Bbr/Smarcd3^tm1.1Bbr Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ either: (involves: 129 * C57BL/6 * SJL) or (involves: 129 * C57BL/6 * ICR * SJL)	abnormal interventricular septum morphology	J:257963
	abnormal myocardial trabeculae morphology	J:257963
	lethality throughout fetal growth and development, complete penetrance	J:257963
	thin myocardium	J:257963
	thin ventricular wall	J:257963
Smarcd3^tm1.1Bbr/Smarcd3^tm1.1Bbr Tg(Myh6-cre)2182Mds/0 either: (involves: 129 * C57BL/6 * FVB/N * SJL) or (involves: 129 * C57BL/6 * FVB/N * ICR * SJL)	abnormal heart echocardiography feature	J:257963
	abnormal intercalated disk morphology	J:257963
	abnormal sarcomere morphology	J:257963
	cardiac interstitial fibrosis	J:257963
	congestive heart failure	J:257963
	decreased cardiac muscle contractility	J:257963
	decreased cardiac output	J:257963
	decreased heart rate	J:257963
	decreased P wave amplitude	J:257963
	dilated heart	J:257963
	dilated heart left ventricle	J:257963
	enlarged heart	J:257963
	increased cardiomyocyte apoptosis	J:257963
	increased QRS amplitude	J:257963
	postnatal growth retardation	J:257963
	postnatal lethality, incomplete penetrance	J:257963
	premature death	J:257963
	prolonged QRS complex duration	J:257963
	prolonged QT interval	J:257963
	shortened PR interval	J:257963
	thin ventricular wall	J:257963
Smarcd3^tm1.2Bbr/Smarcd3^tm1.2Bbr B6.129(Cg)-Smarcd3^tm1.2Bbr	abnormal atrioventricular cushion morphology	J:257963
	abnormal heart development	J:257963
	abnormal interatrial septum morphology	J:257963
	abnormal myocardial trabeculae morphology	J:257963
	embryonic lethality during organogenesis, complete penetrance	J:257963
	thin myocardium compact layer	J:257963
Smarcd3^tm1.2Bbr/Smarcd3^tm1.2Bbr either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL)	abnormal cardiac muscle relaxation	J:257963
	abnormal heart echocardiography feature	J:257963
	abnormal I band morphology	J:257963
	abnormal interventricular septum morphology	J:257963
	abnormal M line morphology	J:257963
	abnormal sarcomere morphology	J:257963
	abnormal Z line morphology	J:257963
	decreased cardiac muscle contractility	J:257963
	decreased fetal cardiomyocyte proliferation	J:257963
	dilated heart	J:257963
	hemorrhage	J:257963
	lethality throughout fetal growth and development, complete penetrance	J:257963
	thin ventricular wall	J:257963
	ventricular septal defect	J:257963

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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