Emc6 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Emc6
ER membrane protein complex subunit 6
MGI:1913298

23 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Emc6^em1Xjz/Emc6^em1Xjz Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: C57BL/6 * C57BL/6J * DBA	abnormal hepatocyte mitochondrial morphology	J:378400
	abnormal hepatocyte morphology	J:378400
	abnormal liver lobule morphology	J:378400
	abnormal liver nodule incidence	J:378400
	abnormal liver parenchyma morphology	J:378400
	dark liver	J:378400
	enlarged liver	J:378400
	increased bile salt level	J:378400
	increased circulating alanine transaminase level	J:378400
	increased circulating alkaline phosphatase level	J:378400
	increased circulating aspartate transaminase level	J:378400
	increased circulating bilirubin level	J:378400
	increased circulating cholesterol level	J:378400
	increased circulating lactate dehydrogenase level	J:378400
	increased circulating triglyceride level	J:378400
	increased hepatocellular carcinoma incidence	J:378400
	liver edema	J:378400
	liver fibrosis	J:378400
	liver inflammation	J:378400
Emc6^{tm1.1(KOMP)Vlcg}/Emc6⁺ C57BL/6N-Emc6^{tm1.1(KOMP)Vlcg}/Ucd	increased hematocrit	J:211773
Emc6^{tm1.1(KOMP)Vlcg}/Emc6^{tm1.1(KOMP)Vlcg} C57BL/6N-Emc6^{tm1.1(KOMP)Vlcg}/Ucd	embryonic lethality prior to organogenesis	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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