Emc6^em1Xjz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Emc6^em1Xjz
• Name: ER membrane protein complex subunit 6; endonuclease-mediated mutation 1, Xianjun Zhu
• MGI ID: MGI:8402975
• Synonyms: Emc6^f
• Gene: Emc6 Location: Chr11:73066345-73067863 bp, - strand Genetic Position: Chr11, 45.25 cM, cytoband B4
• Alliance: Emc6^em1Xjz page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details:

  CRISPR/Cas9-mediated recombination inserted loxP sites in intron 2 and in intron 3 673 bp downstream of exon 2. (J:378400)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Emc6 Mutation: 10 strains or lines available

References

• Original: J:378400 Zhang Y, et al., Unveiling EMC6 as a novel pathogenic determinant in hepatocellular carcinoma: orchestration of lipid metabolism through regulation of lipid droplet-associated enzyme HSD17B13. Oncogene. 2026 Jan;45(2):322-338
• All: 1 reference(s)