Rab11a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rab11a
RAB11A, member RAS oncogene family
MGI:1858202

29 phenotypes from 2 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rab11a^tm1.1Ngao/Rab11a^tm1.1Ngao Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ involves: 129P2/OlaHsd * 129S6/SvEvTac	abnormal intestinal epithelium morphology	J:215917
Rab11a^tm1.1Ngao/Rab11a^tm1.1Ngao Tg(Vil1-cre)997Gum/0 involves: 129S6/SvEvTac * C57BL/6J * SJL	abnormal crypts of Lieberkuhn morphology	J:215917
	abnormal cytokine secretion	J:215917
	abnormal digestive system physiology	J:215917
	abnormal intestinal epithelium morphology	J:215917
	abnormal intestinal goblet cell morphology	J:215917
	abnormal intestine morphology	J:215917
	abnormal intestine physiology	J:215917
	abnormal small intestinal crypt cell proliferation	J:215917
	abnormal small intestinal villus morphology	J:215917
	decreased body size	J:215917
	decreased colon length	J:215917
	decreased small intestinal villus size	J:215917
	increased interleukin-1 beta secretion	J:215917
	increased interleukin-6 secretion	J:215917
	intestinal inflammation	J:215917
	postnatal lethality, incomplete penetrance	J:215917
	premature death	J:215917
Rab11a^tm1.1Ngao/Rab11a^tm1.1Ngao Tg(Vil1-cre/ERT2)23Syr/0 involves: 129S6/SvEvTac * C57BL/6 * DBA/2	abnormal small intestinal crypt cell proliferation	J:215917
	increased interleukin-6 secretion	J:215917
Rab11a^{tm1b(KOMP)Wtsi}/Rab11a⁺ C57BL/6N-Rab11a^{tm1b(KOMP)Wtsi}/J	improved glucose tolerance	J:211773
	persistence of hyaloid vascular system	J:211773
Rab11a^{tm1b(KOMP)Wtsi}/Rab11a^{tm1b(KOMP)Wtsi} B6N(Cg)-Rab11a^{tm1b(KOMP)Wtsi}/J	abnormal egg cylinder morphology	J:279207
	absent head fold	J:279207
	absent primitive node	J:279207
	decreased embryo size	J:279207
	embryonic growth arrest	J:279207
	embryonic lethality prior to organogenesis	J:279207
	embryonic lethality, complete penetrance	J:279207
	failure of primitive streak formation	J:279207
	failure to gastrulate	J:279207
Rab11a^{tm1b(KOMP)Wtsi}/Rab11a^{tm1b(KOMP)Wtsi} C57BL/6N-Rab11a^{tm1b(KOMP)Wtsi}/J	embryonic lethality prior to organogenesis	J:211773
	preweaning lethality, complete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23