85 phenotypes from 11 alleles in 18 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Clcn7tm1.1Aros/Clcn7tm1.1Aros involves: 129P2/OlaHsd * C57BL/6N	decreased body length	J:273179
	decreased survivor rate	J:273179
	failure of tooth eruption	J:273179
	increased bone volume	J:273179
	osteopetrosis	J:273179
Clcn7tm1.1Lex/Clcn7tm1.1Lex involves: 129S5/SvEvBrd * C57BL/6J	abnormal cerebral cortex morphology	J:186049
	abnormal neocortex morphology	J:186049
	abnormal neuron morphology	J:186049
	abnormal posture	J:186049
	abnormal retina pigment epithelium morphology	J:186049
	abnormal stratification in cerebral cortex	J:186049
	absent photoreceptor inner segment	J:186049
	absent photoreceptor outer segment	J:186049
	astrocytosis	J:186049
	cerebral cortex pyramidal cell degeneration	J:186049
	lysosomal protein accumulation	J:186049
	microgliosis	J:186049
	neurodegeneration	J:186049
	postnatal growth retardation	J:186049
	respiratory failure	J:186049
	retina degeneration	J:186049
	normal skeleton phenotype	J:186049
	thin retina inner nuclear layer	J:186049
	thin retina outer nuclear layer	J:186049
	tonic seizures	J:186049
	tremors	J:186049
	normal vision/eye phenotype	J:186049
Clcn7tm1.1Mawa/Clcn7+ involves: C57BL/6J * C57BL/6N * CD-1	decreased bone strength	J:254787
	decreased bone trabecular spacing	J:254787
	decreased compact bone area	J:254787
	decreased compact bone thickness	J:254787
	increased bone mineral density	J:254787
	increased bone trabecula number	J:254787
	increased osteoclast cell number	J:254787
	increased trabecular bone thickness	J:254787
	increased trabecular bone volume	J:254787
	osteopetrosis	J:254787
Clcn7tm1.1Mawa/Clcn7tm1.1Mawa involves: C57BL/6J * C57BL/6N * CD-1	decreased body size	J:254787
	failure of tooth eruption	J:254787
	increased bone mineral density	J:254787
	premature death	J:254787
Clcn7tm1.1Mawa/Clcn7tm1.1Mjec involves: 129 * C57BL/6J * C57BL/6N * CD-1	decreased body size	J:254787
	failure of tooth eruption	J:254787
	premature death	J:254787
Clcn7tm1.1Mjec/Clcn7+ involves: 129 * 129S/SvEv * C57BL/6	decreased bone trabecular spacing	J:203761
	increased areal bone mineral density	J:203761
	increased bone trabecula number	J:203761
	increased trabecular bone volume	J:203761
Clcn7tm1.1Mjec/Clcn7+ involves: 129S/SvEv * BALB/cJ * C57BL/6	increased bone mineral density	J:203761
	increased trabecular bone volume	J:203761
Clcn7tm1.1Mjec/Clcn7+ involves: 129S/SvEv * C57BL/6 * DBA/2J	abnormal trabecular bone morphology	J:203761
	increased bone mineral density	J:203761
	increased bone trabecula number	J:203761
	increased circulating alkaline phosphatase level	J:203761
	increased trabecular bone volume	J:203761
Clcn7tm1.1Teti/Clcn7+ involves: 129S2/SvPas * C57BL/6	abnormal bone marrow morphology	J:203761
	abnormal osteoclast physiology	J:203761
	decreased bone resorption	J:203761
	decreased bone trabecular spacing	J:203761
	increased areal bone mineral density	J:203761
	increased bone mass	J:203761
	increased bone trabecula number	J:203761
	increased circulating parathyroid hormone level	J:203761
	increased osteoclast cell number	J:203761
	increased trabecular bone volume	J:203761
	normal nervous system phenotype	J:203761
	osteopetrosis	J:203761
Clcn7tm1.1Teti/Clcn7tm1.1Teti involves: 129S2/SvPas * C57BL/6	decreased body size	J:203761
	failure of tooth eruption	J:203761
	myelofibrosis	J:203761
	neurodegeneration	J:203761
	osteopetrosis	J:203761
	premature death	J:203761
	Purkinje cell degeneration	J:203761
Clcn7tm1.1Teti/Clcn7tm1.1Teti involves: 129S2/SvPas * CD-1	decreased body size	J:203761
	failure of tooth eruption	J:203761
	osteopetrosis	J:203761
	premature death	J:203761
Clcn7tm1Tjj/Clcn7tm1Tjj involves: 129P2/OlaHsd * C57BL/6	abnormal bone marrow cavity morphology	J:67273
	abnormal bone ossification	J:67273
	abnormal head morphology	J:67273
	abnormal osteoclast morphology	J:67273
	abnormal osteoclast physiology	J:67273
	decreased body size	J:67273
	decreased bone resorption	J:67273
	failure of tooth eruption	J:67273
	increased osteoblast cell number	J:67273
	optic nerve degeneration	J:67273
	osteopetrosis	J:67273
	postnatal lethality, incomplete penetrance	J:67273
	retina degeneration	J:67273
	short limbs	J:67273
Clcn7tm2.1Mjec/Clcn7tm2.1Mjec 129(Cg)-Clcn7tm2.1Mjec	decreased body weight	J:240468
	increased areal bone mineral density	J:240468
	increased bone mineral content	J:240468
	increased bone trabecula number	J:240468
	increased trabecular bone thickness	J:240468
	increased trabecular bone volume	J:240468
Clcn7tm2.1Mjec/Clcn7tm2.1Mjec B6.129(Cg)-Clcn7tm2.1Mjec	increased areal bone mineral density	J:240468
	increased body weight	J:240468
	increased bone mineral content	J:240468
	increased bone trabecula number	J:240468
	increased trabecular bone volume	J:240468
Clcn7tm2.1Mjec/Clcn7tm2.1Mjec C.129(Cg)-Clcn7tm2.1Mjec	increased areal bone mineral density	J:240468
	increased body weight	J:240468
	increased bone mineral content	J:240468
	increased bone trabecula number	J:240468
	increased trabecular bone thickness	J:240468
	increased trabecular bone volume	J:240468
Clcn7tm2.1Mjec/Clcn7tm2.1Mjec D2.129(Cg)-Clcn7tm2.1Mjec	decreased body weight	J:240468
	increased areal bone mineral density	J:240468
	increased bone mineral content	J:240468
	increased bone trabecula number	J:240468
	increased trabecular bone thickness	J:240468
	increased trabecular bone volume	J:240468
Clcn7tm2Tjj/Clcn7tm2Tjj involves: 129S1/Sv * 129X1/SvJ	abnormal lysosome physiology	J:155176
	accumulation of giant lysosomes in kidney/renal tubule cells	J:155176
	astrocytosis	J:155176
	enhanced autophagy	J:155176
	microgliosis	J:155176
Clcn7tm2Tjj/Clcn7tm2Tjj involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal autophagy	J:217031
	abnormal bone marrow cavity morphology	J:67273
	abnormal bone ossification	J:67273
	abnormal coat/hair pigmentation	J:217031
	abnormal hair shaft melanin granule distribution	J:217031
	abnormal head morphology	J:67273
	abnormal osteoclast morphology	J:67273, J:217031
	abnormal osteoclast physiology	J:67273
	decreased body size	J:67273
	failure of tooth eruption	J:67273
	increased osteoblast cell number	J:67273
	increased trabecular bone volume	J:217031
	optic nerve degeneration	J:67273
	osteopetrosis	J:67273, J:217031
	postnatal lethality, incomplete penetrance	J:67273
	retina degeneration	J:67273, J:217031
	short limbs	J:67273
Clcn7tm3.1Tjj/Clcn7tm3.1Tjj Emx1tm1.1(cre)Ito/Emx1+ involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6	abnormal cerebral cortex morphology	J:155176
	abnormal dentate gyrus morphology	J:155176
	abnormal hippocampus morphology	J:155176
	abnormal lysosome physiology	J:155176
	astrocytosis	J:155176
	enlarged lateral ventricles	J:155176
	normal growth/size/body region phenotype	J:155176
	hippocampal neuron degeneration	J:155176
	limb grasping	J:155176
	loss of cortex neurons	J:155176
	loss of hippocampal neurons	J:155176
	microgliosis	J:155176
	normal mortality/aging	J:155176
	neurodegeneration	J:155176
	normal skeleton phenotype	J:155176
Clcn7tm3.1Tjj/Clcn7tm3.1Tjj Tg(APOE-cre)VITew/0 B6.Cg-Clcn7tm3.1Tjj Tg(APOE-cre)VITew	abnormal lysosome physiology	J:155176
	accumulation of giant lysosomes in kidney/renal tubule cells	J:155176
Clcn7tm4.1Tjj/Clcn7+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	hippocampal neuron degeneration	J:160702
	retina degeneration	J:160702
Clcn7tm4.1Tjj/Clcn7tm4.1Tjj involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal autophagy	J:217031
	abnormal lysosome physiology	J:160702
	abnormal osteoclast morphology	J:160702, J:217031
	abnormal osteoclast physiology	J:160702
	abnormal tooth eruption	J:160702
	abnormal trabecular bone morphology	J:160702
	decreased body weight	J:160702
	increased bone mineral density	J:160702
	increased trabecular bone thickness	J:160702
	neurodegeneration	J:160702
	osteopetrosis	J:160702, J:217031
	normal pigmentation phenotype	J:160702, J:217031
	postnatal growth retardation	J:160702
	premature death	J:160702
	retina degeneration	J:160702, J:217031
	small cranium	J:160702
Clcn7tm5.1Tjj/Clcn7+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	no abnormal phenotype detected	J:217031
Clcn7tm5.1Tjj/Clcn7tm5.1Tjj involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal cerebral cortex morphology	J:217031
	abnormal chloride level	J:217031
	abnormal hippocampus neuron morphology	J:217031
	abnormal hippocampus pyramidal cell morphology	J:217031
	abnormal lysosome morphology	J:217031
	abnormal lysosome physiology	J:217031
	abnormal osteoclast morphology	J:217031
	normal cellular phenotype	J:217031
	failure of tooth eruption	J:217031
	hippocampal neuron degeneration	J:217031
	hippocampus pyramidal cell degeneration	J:217031
	increased trabecular bone volume	J:217031
	neurodegeneration	J:217031
	osteopetrosis	J:217031
	normal pigmentation phenotype	J:217031
	postnatal growth retardation	J:217031
	premature death	J:217031
	normal vision/eye phenotype	J:217031