Clcn7^tm3.1Tjj
Targeted Allele Detail

Summary

• Symbol: Clcn7^tm3.1Tjj
• Name: chloride channel, voltage-sensitive 7; targeted mutation 3.1, Thomas J Jentsch
• MGI ID: MGI:4413670
• Synonyms: Clcn7^lox
• Gene: Clcn7 Location: Chr17:25352365-25381078 bp, + strand Genetic Position: Chr17, 12.53 cM, cytoband A3.3
• Alliance: Clcn7^tm3.1Tjj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155176
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was upstream of exon 12 and a floxed neo cassette was inserted downstream of exon 13. Cre mediated recombination removed the neo cassette leaving exons 12 and 13 floxed. (J:155176)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clcn7 Mutation: 40 strains or lines available

References

• Original: J:155176 Wartosch L, et al., Lysosomal degradation of endocytosed proteins depends on the chloride transport protein ClC-7. FASEB J. 2009 Dec;23(12):4056-68
• All: 1 reference(s)