Cth Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cth
cystathionine gamma lyase
MGI:1339968

34 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cth^{tm1b(EUCOMM)Hmgu}/Cth^{tm1b(EUCOMM)Hmgu} C57BL/6N-Cth^{tm1b(EUCOMM)Hmgu}/Ieg	abnormal lens morphology	J:211773
	abnormal retina morphology	J:211773
	abnormal retina vasculature morphology	J:211773
	decreased exploration in new environment	J:211773
	persistence of hyaloid vascular system	J:211773
Cth^tm1Iish/Cth⁺ B6.129-Cth^tm1Iish/Iish	increased circulating homocysteine level	J:166184
Cth^tm1Iish/Cth^tm1Iish B6.129-Cth^tm1Iish/Iish	abnormal circulating amino acid level	J:166184
	abnormal liver morphology	J:166184
	normal cardiovascular system phenotype	J:166184
	cystathioninuria	J:166184
	decreased circulating creatinine level	J:166184
	decreased circulating taurine level	J:166184
	decreased glutathione level	J:166184
	decreased lactate dehydrogenase level	J:166184
	decreased skeletal muscle fiber diameter	J:166184
	increased blood urea nitrogen level	J:166184
	increased cellular sensitivity to oxidative stress	J:166184
	increased circulating alanine transaminase level	J:166184
	increased circulating alkaline phosphatase level	J:166184
	increased circulating aspartate transaminase level	J:166184
	increased circulating homocysteine level	J:166184
	increased circulating serum albumin level	J:166184
	increased circulating triglyceride level	J:166184
	increased sensitivity to induced cell death	J:166184
	increased susceptibility to induced morbidity/mortality	J:166184
	increased susceptibility to induced muscular atrophy	J:166184
	increased susceptibility to weight loss	J:166184
	paralysis	J:166184
	postnatal growth retardation	J:166184
Cth^tm1Liwu/Cth⁺ involves: 129S/SvEvBrd * C57BL/6J	decreased circulating cysteine level	J:140705
	hypertension	J:140705
	increased circulating homocysteine level	J:140705
Cth^tm1Liwu/Cth^tm1Liwu involves: 129S/SvEvBrd * C57BL/6J	decreased circulating cysteine level	J:140705
	decreased physiological sensitivity to xenobiotic	J:140705
	decreased vasodilation	J:140705
	hypertension	J:140705
	increased circulating homocysteine level	J:140705
	increased physiological sensitivity to xenobiotic	J:140705
	normal renal/urinary system phenotype	J:140705

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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