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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Diaph1
diaphanous related formin 1
MGI:1194490
45 phenotypes from 6 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Diaph1em1(IMPC)Rbrc/Diaph1em1(IMPC)Rbrc
C57BL/6NJcl-Diaph1em1(IMPC)Rbrc/Rbrc
increased blood urea nitrogen level J:211773
Diaph1M1Btlr/Diaph1+
C57BL/6J-Diaph1M1Btlr
abnormal CD4-positive, alpha-beta T cell number J:254820
abnormal CD8-positive, alpha-beta T cell number J:254820
decreased IgE level J:254820
increased central memory CD4-positive, alpha-beta T cell number J:254820
increased central memory CD8 positive, alpha-beta T cell number J:254820
Diaph1M1Btlr/Diaph1M1Btlr
C57BL/6J-Diaph1M1Btlr
abnormal CD4-positive, alpha-beta T cell number J:254820
abnormal CD8-positive, alpha-beta T cell number J:254820
decreased effector memory CD8-positive, alpha-beta T cell number J:254820
decreased IgE level J:254820
increased central memory CD4-positive, alpha-beta T cell number J:254820
increased central memory CD8 positive, alpha-beta T cell number J:254820
increased susceptibility to Herpesvirales infection induced morbidity/mortality J:254820
Diaph1M2Btlr/Diaph1+
C57BL/6J-Diaph1M2Btlr
decreased B-1 B cell number J:254819
Diaph1M2Btlr/Diaph1M2Btlr
C57BL/6J-Diaph1M2Btlr
decreased B-1 B cell number J:254819
decreased CD8-positive, alpha-beta memory T cell number J:254819
Diaph1m3Btlr/Diaph1m3Btlr
C57BL/6J-Diaph1m3Btlr
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:254818
decreased CD8-positive, naive alpha-beta T cell number J:254818
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:254818
increased CD8-positive, alpha-beta memory T cell number J:254818
increased central memory CD4-positive, alpha-beta T cell number J:254818
increased central memory CD8 positive, alpha-beta T cell number J:254818
increased effector memory CD4-positive, alpha-beta T cell number J:254818
increased effector memory CD8-positive, alpha-beta T cell number J:254818
Diaph1tm1.1Sna/Diaph1tm1.1Sna
B6.Cg-Diaph1tm1.1Sna
abnormal humoral immune response J:126090
abnormal leukocyte migration J:126090
decreased CD4-positive, alpha-beta T cell number J:126090
decreased CD8-positive, alpha-beta T cell number J:126090
decreased T cell number J:126090
decreased T cell proliferation J:126090
increased single-positive T cell number J:126090
Diaph1tm1Asal/Diaph1+
involves: 129S1/Sv * C57BL/6
abnormal bone marrow cell morphology/development J:124319
abnormal definitive hematopoiesis J:124319
increased bone marrow cell number J:124319
Diaph1tm1Asal/Diaph1tm1Asal
involves: 129S1/Sv * C57BL/6
abnormal bone marrow cell morphology/development J:124319
abnormal definitive hematopoiesis J:124319
abnormal lymph node morphology J:124319
abnormal skin condition J:124319
abnormal spleen germinal center morphology J:124319
abnormal spleen morphology J:124319
absent spleen white pulp J:124319
alopecia J:124319
anemia J:124319
decreased lymphocyte cell number J:124319
dehydration J:124319
dermatitis J:124319
echinocytosis J:124319
extramedullary hematopoiesis J:124319
increased bone marrow cell number J:124319
increased granulocyte number J:124319
increased leukocyte cell number J:124319
increased monocyte cell number J:124319
increased neutrophil cell number J:124319
increased spleen weight J:124319
malocclusion J:124319
postnatal growth retardation J:124319

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory