Pitx3 Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pitx3
paired-like homeodomain transcription factor 3
MGI:1100498

17 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Pitx3^tm1.1Cai/Pitx3⁺ Tg(tetO-SNCAA53T)E2Cai/0 involves: 129 C57BL/6J * FVB/N	abnormal autophagy	J:185958
	abnormal dopaminergic neuron morphology	J:185958
	abnormal gait	J:185958
	abnormal neurite morphology	J:185958
	abnormal neuron physiology	J:185958
	abnormal synaptic dopamine release	J:185958
	alpha-synuclein inclusion body	J:185958
	astrocytosis	J:185958
	decreased dopamine level	J:185958
	decreased locomotor activity	J:185958
	decreased vertical activity	J:185958
	impaired coordination	J:185958
	loss of dopaminergic neurons	J:185958
	microgliosis	J:185958
	neuron degeneration	J:185958
	short stride length	J:185958
	slow postnatal weight gain	J:185958

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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