Pitx3^tm1.1Cai
Targeted Allele Detail

Summary

• Symbol: Pitx3^tm1.1Cai
• Name: paired-like homeodomain transcription factor 3; targeted mutation 1.1, Huaibin Cai
• MGI ID: MGI:5432011
• Synonyms: PITX3-IRES2-tTA
• Gene: Pitx3 Location: Chr19:46124124-46136765 bp, - strand Genetic Position: Chr19, 38.75 cM
• Alliance: Pitx3^tm1.1Cai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185958
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Transactivator)
• Mutation: Insertion
• Mutation details: A targeting vector inserted an IRES2, tetracycline transactivator domain (tTA) and floxed neo cassette were inserted downstream of exon 4. Cre mediated recombination removed the neo cassette. (J:185958)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pitx3 Mutation: 22 strains or lines available

References

• Original: J:185958 Lin X, et al., Conditional Expression of Parkinson's Disease-Related Mutant alpha-Synuclein in the Midbrain Dopaminergic Neurons Causes Progressive Neurodegeneration and Degradation of Transcription Factor Nuclear Receptor Related 1. J Neurosci. 2012 Jul 4;32(27):9248-64
• All: 12 reference(s)