Hfe Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hfe
homeostatic iron regulator
MGI:109191

40 phenotypes from 11 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
\Hfe^tm1.1Gfn/\Hfe^tm1.1Gfn B6.129P2-Hfe^tm1.1Gfn	abnormal gait	J:114351
	abnormal pilomotor reflex	J:114351
	abnormal postural reflex	J:114351
	decreased body length	J:114351
	impaired coordination	J:114351
	induced hyperactivity	J:114351
	short tail	J:114351
\Hfe^tm1.1Jrco/\Hfe⁺ involves: 129X1/SvJ * C57BL/6J	oxidative stress	J:201948
\Hfe^tm1.1Jrco/\Hfe^tm1.1Jrco involves: 129X1/SvJ * C57BL/6J	abnormal brain iron level	J:201948
	astrocytosis	J:201948
	increased body weight	J:201948
	increased liver iron level	J:201948
	oxidative stress	J:201948
\Hfe^tm1.1Nca/\Hfe^tm1.1Nca involves: 129S6/SvEvTac	abnormal iron level	J:78536
\Hfe^tm1.1Nca/\Hfe^tm1.1Nca involves: 129S6/SvEvTac * C57BL/6J	abnormal iron level	J:78536
\Hfe^tm1.1Nca/\Hfe^tm1.1Nca Not Specified	increased liver iron level	J:62112
\Hfe^tm1.1Wsr/\Hfe^tm1.1Wsr involves: 129P2/OlaHsd * C57BL/6	abnormal iron homeostasis	J:141745
	decreased spleen iron level	J:132134
	hemochromatosis	J:132134
	increased circulating iron level	J:132134, J:132141
	increased liver iron level	J:132134, J:132141, J:141745
\Hfe^tm1Gfn/\Hfe^tm1Gfn involves: 129P2/OlaHsd * C57BL/6	abnormal iron homeostasis	J:68025
	abnormal iron level	J:262906
	abnormal trabecular bone morphology	J:262906
	decreased bone trabecula number	J:262906
	decreased trabecular bone thickness	J:262906
	decreased trabecular bone volume	J:262906
	increased body weight	J:262906
	increased circulating iron level	J:68025
	increased liver iron level	J:68025, J:262906
	increased osteoclast cell number	J:262906
	increased spleen iron level	J:68025
	osteoporosis	J:262906
\Hfe^tm1Sly/\Hfe^tm1Sly Not Specified	increased liver iron level	J:88143
\Hfe^tm1Sly/\Hfe^tm2Sly involves: 129X1/SvJ * C57BL/6J	increased liver iron level	J:88143
\Hfe^tm1Wsr/\Hfe^tm1Wsr \Lyz2^tm1(cre)Ifo/? involves: 129P2/OlaHsd * C57BL/6	normal homeostasis/metabolism phenotype	J:132134
\Hfe^tm1Wsr/\Hfe^tm1Wsr \Tg(Alb1-cre)7Gsc/? involves: 129P2/OlaHsd * C57BL/6 * FVB/N	decreased spleen iron level	J:132134
	hemochromatosis	J:132134
	increased circulating iron level	J:132134
	increased liver iron level	J:132134
\Hfe^tm1Wsr/\Hfe^tm1Wsr \Tg(Vil1-cre)997Gum/? involves: 129P2/OlaHsd * C57BL/6 * SJL	no abnormal phenotype detected	J:141745
\Hfe^tm2Nca/\Hfe⁺ involves: 129S6/SvEvTac	increased liver iron level	J:62112
\Hfe^tm2Nca/\Hfe^tm2Nca involves: 129S6/SvEvTac	abnormal iron level	J:78536
	decreased spleen iron level	J:78536
	increased circulating iron level	J:133221
	increased liver iron level	J:62112, J:133221
\Hfe^tm2Nca/\Hfe^tm2Nca involves: 129S6/SvEvTac * C57BL/6J	abnormal iron level	J:78536
\Hfe^tm2Nca/\Hfe^tm2Nca involves: 129S6/SvEvTac * C57BL/6J	decreased spleen iron level	J:78536
\Hfe^tm2Nca/\Hfe^tm2Nca \Tg(Ttr-Hfe)1Nca/0 involves: 129S6/SvEvTac * C57BL/6	decreased circulating iron level	J:133221
	decreased liver iron level	J:133221
	hypochromic microcytic anemia	J:133221
\Hfe^tm2Sly/\Hfe^tm2Sly involves: 129X1/SvJ * C57BL/6J	abnormal brain iron level	J:213886
	abnormal brain size	J:213886
	abnormal object recognition memory	J:213886
	abnormal response to novel object	J:213886
	abnormal spatial reference memory	J:213886
	abnormal spatial working memory	J:213886
	decreased brain cholesterol level	J:213886
	decreased brain weight	J:213886
	decreased corpus callosum size	J:213886
	enlarged brain ventricles	J:213886
	impaired spatial learning	J:213886
	increased liver iron level	J:88143
	neuron degeneration	J:213886
\Hfe^tm2Sly/\Hfe^tm3Sly involves: 129X1/SvJ * C57BL/6J	increased liver iron level	J:88143
\Hfe^tm3Sly/\Hfe^tm3Sly involves: 129X1/SvJ * C57BL/6J	increased liver iron level	J:88143

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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