Tubb4a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tubb4a
tubulin, beta 4A class IVA
MGI:107848

33 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ifi208^{Tg(Cspg4-cre)1Akik}/Ifi208⁺ Tubb4a^Jit/Tubb4a^{tm1c(EUCOMM)Hmgu} involves: C57BL/6 * C57BL/6N * FVB/N * SJL	dysmyelination	J:321692
Tubb4a^em1Avan/Tubb4a⁺ involves: C57BL/6	normal behavior/neurological phenotype	J:291062
	decreased myelin sheath thickness	J:291062
	demyelination	J:291062
	dysmyelination	J:291062
Tubb4a^em1Avan/Tubb4a^em1Avan involves: C57BL/6	abnormal axon morphology	J:291062
	abnormal brain development	J:291062
	abnormal cerebellar granule layer morphology	J:291062
	abnormal gait	J:291062
	abnormal myelination	J:291062
	astrocytosis	J:291062
	ataxia	J:291062
	axon degeneration	J:291062
	decreased grip strength	J:291062
	decreased myelin sheath thickness	J:291062
	decreased oligodendrocyte number	J:291062
	demyelination	J:291062
	dysmyelination	J:291062
	dystonia	J:291062
	impaired coordination	J:291062
	impaired righting response	J:291062
	motor developmental delay	J:291062
	neuron degeneration	J:291062
	premature death	J:291062
	tremors	J:291062
	weight loss	J:291062
Tubb4a^Jit/Tubb4a⁺ FVB.B6-Tubb4a^Jit	abnormal cerebellar granule cell morphology	J:321692
	ataxia	J:321692
	cerebellum atrophy	J:321692
	dysmyelination	J:321692
	impaired coordination	J:321692
Tubb4a^Jit/Tubb4a^Jit FVB.B6-Tubb4a^Jit	abnormal cerebellar granule cell morphology	J:321692
	abnormal cerebellum morphology	J:321692
	abnormal nervous system tract morphology	J:321692
	abnormal oligodendrocyte physiology	J:321692
	ataxia	J:321692
	cerebellum atrophy	J:321692
	dysmyelination	J:321692
	increased neuron apoptosis	J:321692
	neuron degeneration	J:321692
	premature death	J:321692
	thin cerebellar granule layer	J:321692
	thin cerebellar molecular layer	J:321692
Tubb4a^Jit/Tubb4a^{tm1(KOMP)Wtsi} involves: C57BL/6 * C57BL/6N * FVB/N	abnormal cerebellar granule cell morphology	J:321692
	abnormal motor capabilities/coordination/movement	J:321692
	abnormal nervous system tract morphology	J:321692
	cerebellum atrophy	J:321692
	dysmyelination	J:321692
	premature death	J:321692
Tubb4a^Jit/Tubb4a^{tm1c(EUCOMM)Hmgu} Tg(Atoh1-cre)1Bfri/0 involves: C57BL/6 * C57BL/6N * CBA * FVB/N	abnormal cerebellar granule cell morphology	J:321692
Tubb4a^{tm1(KOMP)Wtsi}/Tubb4a^{tm1(KOMP)Wtsi} involves: C57BL/6N * FVB/N	normal behavior/neurological phenotype	J:321692
	normal mortality/aging	J:321692
Tubb4a^{tm1.1(KOMP)Wtsi}/Tubb4a^{tm1.1(KOMP)Wtsi} C57BL/6N-Tubb4a^{tm1.1(KOMP)Wtsi}/J	decreased fasting circulating glucose level	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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